Core K - Current HIV research often requires reliable links between clinical and basic science investigators. These links include characterization and access to clinical specimens, laboratory based assays designed for clinical specimens, interpretation and management of generated data, and training in these areas. The Translational Virology (TV) Core of the UCSD CFAR is designed to be this reliable and cost-effective link. The TV Core accomplishes this goal for a wide range of HIV research-related activities involving: junior and senior investigators, established and burgeoning programs, clinical and basic science investigators, domestic and International efforts, NIH and other funders, etc. Over the past 4 years, the TV Core has provided services to 67 Investigators, contributed to 56 publications, helped 11 investigators obtain new or competing research awards and trained 48 individuals in safe laboratory procedures for working with HIV and PCR methodologies. Specifically, the TV Core provides services through four defined units that work closely with other CFAR Cores, as outlined: (1) Specimen Unit: obtains, processes, tracks, ships and cryostores samples, (primary collaborating Core: Clinical Investigation and Biostatistics) (2) Assay Unit: develops and provides a wide-range of clinically-relevant assays (HIV genotyping, viral loads, antibody and nucleic acid detection, etc.). (primary collaborating Core: Genomics and Sequencing) (3) Quality Control Unit: provides quality control procedures for domestic and International CFAR-affiliated investigators, and analytical support for generated data, (primary collaborating Core: Bioinformatics and Information Technologies) (4) Training Unit: provides training and certification in BL2 and BL3 safety and procedures, specimen processing, PCR, genotyping techniques, and laboratory quality assurance, (primary collaborating Cores: Developmental and International).
The Translational Virology (TV) Core provides essential Infrastructure and services to support new and ongoing HIV research through the UCSD CFAR. Specifically, the TV Core provides research support in clinical specimen management, relevant assays, analysis and quality assurance of assay data, and lab training. These services support the HIV research needed to better the lives of people living with HIV and for the public health as a whole.
|Heaton, Robert K; Franklin Jr, Donald R; Deutsch, Reena et al. (2015) Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study. Clin Infect Dis 60:473-80|
|Hepler, N Lance; Scheffler, Konrad; Weaver, Steven et al. (2014) IDEPI: rapid prediction of HIV-1 antibody epitopes and other phenotypic features from sequence data using a flexible machine learning platform. PLoS Comput Biol 10:e1003842|
|Szumowski, Suzannah C; Botts, Michael R; Popovich, John J et al. (2014) The small GTPase RAB-11 directs polarized exocytosis of the intracellular pathogen N. parisii for fecal-oral transmission from C. elegans. Proc Natl Acad Sci U S A 111:8215-20|
|Murrell, Ben; Murrell, Daniel; Murrell, Hugh (2014) R2-equitability is satisfiable. Proc Natl Acad Sci U S A 111:E2160|
|Grant, Igor; Franklin Jr, Donald R; Deutsch, Reena et al. (2014) Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology 82:2055-62|
|Blattner, Claudia; Lee, Jeong Hyun; Sliepen, Kwinten et al. (2014) Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers. Immunity 40:669-80|
|Cachay, Edward R (2014) The forgotten component in the staging and management of HIV/hepatitis C virus-coinfected patients. Clin Infect Dis 59:320-1|
|Jeong, Su Jin; Kim, Min Hyung; Song, Je Eun et al. (2014) Short communication: prospective comparison of qualitative versus quantitative polymerase chain reaction for monitoring virologic treatment failure in HIV-infected patients. AIDS Res Hum Retroviruses 30:827-9|
|Wang, Cathy X; Sather, Blythe D; Wang, Xuefeng et al. (2014) Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells. Blood 124:913-23|
|Scheffler, Konrad; Murrell, Ben; Kosakovsky Pond, Sergei L (2014) On the validity of evolutionary models with site-specific parameters. PLoS One 9:e94534|
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