The CFAR Immune Function Core makes available sophisticated immunologic services to CFAR researchers at all levels of expertise. The Core facilitates access to reagents, state-of-the-art instrumentation and performs complex immunological assays in response to user requests.
The specific aims of the Immune Function core are: ? To operate, maintain and provide access to a wide array of instruments needed for modern immunology including multi-color flow cytometers, plate readers, imaging, bead array reader. ? To perform a wide range of immunological assays including ELISA, ELISPOT, multi-plexed cytokine levels, western blotting, and flow cytometry in response to user requests ? To provide access to discount purchasing of reagents, kits and antibodies and access to immunologic reagents available in small test quantifies ? To provide training on instrument use and consultation about the design of immunological assays.

Public Health Relevance

Understanding of HIV immunology is important for vaccine development, disease pathogenesis and immune restoration in HIV disease. This core provides services to CFAR faculty who require access to flow cytometry and other methods for evaluating immune functions.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30AI036219-20
Application #
8641305
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Freeman, Michael L; Lederman, Michael M; Gianella, Sara (2016) Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection. Curr HIV/AIDS Rep 13:10-9
Veazey, R S; Pilch-Cooper, H A; Hope, T J et al. (2016) Prevention of SHIV transmission by topical IFN-β treatment. Mucosal Immunol 9:1528-1536
Hirsch, Christina S; Rojas, Roxana; Wu, Mianda et al. (2016) Mycobacterium tuberculosis Induces Expansion of Foxp3 Positive CD4 T-cells with a Regulatory Profile in Tuberculin Non-sensitized Healthy Subjects: Implications for Effective Immunization against TB. J Clin Cell Immunol 7:
Althoff, Keri N; Rebeiro, Peter F; Hanna, David B et al. (2016) A picture is worth a thousand words: maps of HIV indicators to inform research, programs, and policy from NA-ACCORD and CCASAnet clinical cohorts. J Int AIDS Soc 19:20707
Hrecka, Kasia; Hao, Caili; Shun, Ming-Chieh et al. (2016) HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins. Proc Natl Acad Sci U S A 113:E3921-30
Valadkhan, Saba; Gunawardane, Lalith S (2016) lncRNA-mediated regulation of the interferon response. Virus Res 212:127-36
Reyes-Rodriguez, Angel L; Reuter, Morgan A; McDonald, David (2016) Dendritic Cells Enhance HIV Infection of Memory CD4(+) T Cells in Human Lymphoid Tissues. AIDS Res Hum Retroviruses 32:203-10
Li, Jonathan Z; Etemad, Behzad; Ahmed, Hayat et al. (2016) The size of the expressed HIV reservoir predicts timing of viral rebound after treatment interruption. AIDS 30:343-53
Gianella, Sara; Letendre, Scott (2016) Cytomegalovirus and HIV: A Dangerous Pas de Deux. J Infect Dis 214 Suppl 2:S67-74
Klein, Marina B; Althoff, Keri N; Jing, Yuezhou et al. (2016) Risk of End-Stage Liver Disease in HIV-Viral Hepatitis Coinfected Persons in North America From the Early to Modern Antiretroviral Therapy Eras. Clin Infect Dis 63:1160-1167

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