Core A ? Administrative Core The CWRU/UH CFAR Administrative Core is responsible for driving the direction of the HIV/AIDS research at our institutions while at the same time responding to evolving research needs of CFAR investigators. The Administrative Core provides the leadership and organizational structure to coordinate, support and enhance the efforts of the 102 Full members, 53 Associate members, who are students, postdoctoral fellows and research associates and 21 International members from Uganda, South Africa, and Britain that make up the CFAR. Major scientific strengths leveraged by the CWRU/UH CFAR include international research based on our 26 year collaboration with colleagues in Uganda, immune pathogenesis, basic virology and Cure research, and clinical trials. The Administrative Core has developed a thoughtful and responsive Strategic Planning process developed with input from CFAR members and institutional leaders. Implementation of the Strategic Plan includes strengthening and realigning the Cores, using institutional funds to invest in key new technologies for the Cores, effective fiscal controls for the CFAR, outreach programs to inform CFAR investigators and the local community of recent progress and events, and methods to foster cross-CFAR linkages.
The Specific Aims for the Case CWRU/CFAR Administrative Core A are: To coordinate a rigorous annual review and scientific planning process and to implement the plan through enhancement of Core services, recruitment, and stimulating new research activities. To leverage institutional support to enhance HIV/AIDS research at our institutions. To support our long-standing commitment to HIV/AIDS research in Uganda. The CFAR operates one of the most advanced scientific laboratories in sub-Saharan Africa. To stimulate training activities throughout the CFAR. To improve communications throughout the CFAR and oversee Biosafety activities. To participate in collaborative research efforts within the national CFAR network. In summary, the Administrative Core provides effective leadership for the CFAR by using its resources to generate and implement a well-conceived strategic plan. When unexpected events happen, due to Faculty recruitment or turnover, or changes in the HIV research agenda due to new scientific advances, the Core has demonstrated that it can respond in a rapid and effective fashion.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036219-25
Application #
9690566
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
25
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Kityo, Cissy; Makamdop, Krystelle Nganou; Rothenberger, Meghan et al. (2018) Lymphoid tissue fibrosis is associated with impaired vaccine responses. J Clin Invest 128:2763-2773
Wiredja, Danica D; Tabler, Caroline O; Schlatzer, Daniela M et al. (2018) Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells. Retrovirology 15:44
Oliveira, Vitor H F; Perazzo, Joseph D; Josephson, Richard A et al. (2018) Association Between the 6-Minute Walk Test Distance and Peak Cardiorespiratory Fitness Among People Living with HIV Varies by Fitness Level. J Assoc Nurses AIDS Care 29:775-781
Paparisto, Ermela; Woods, Matthew W; Coleman, Macon D et al. (2018) Evolution-Guided Structural and Functional Analyses of the HERC Family Reveal an Ancient Marine Origin and Determinants of Antiviral Activity. J Virol 92:
Llewellyn, George N; Alvarez-Carbonell, David; Chateau, Morgan et al. (2018) HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. J Neurovirol 24:192-203
Longenecker, Chris T; Sullivan, Claire E; Morrison, Justin et al. (2018) The effects of HIV and smoking on aortic and splenic inflammation. AIDS 32:89-94
Tomas, Myreen E; Mana, Thriveen S C; Wilson, Brigid M et al. (2018) Tapering Courses of Oral Vancomycin Induce Persistent Disruption of the Microbiota That Provide Colonization Resistance to Clostridium difficile and Vancomycin-Resistant Enterococci in Mice. Antimicrob Agents Chemother 62:
Yanik, Elizabeth L; Hernández-Ramírez, Raúl U; Qin, Li et al. (2018) Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada. J Acquir Immune Defic Syndr 78:499-504
Sahmoudi, Karima; Abbassi, Hassan; Bouklata, Nada et al. (2018) Immune activation and regulatory T cells in Mycobacterium tuberculosis infected lymph nodes. BMC Immunol 19:33
Webel, Allison R; Moore, Shirley M; Longenecker, Chris T et al. (2018) Randomized Controlled Trial of the SystemCHANGE Intervention on Behaviors Related to Cardiovascular Risk in HIV+ Adults. J Acquir Immune Defic Syndr 78:23-33

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