The UMass CFAR Clinical Core's mission is to provide the infrastructure and services that promote innovative patient-oriented and translational HIV research. The CFAR Clinical Core has the following goals: 1) To facilitate interactions between basic scientists and clinical investigators that lead to patient-oriented studies that improve our understanding of HIV pathogenesis and the development of novel prevention or treatment strategies;2) To provide the necessary expertise and services to facilitate patient-oriented and translational research;3) To coordinate services with other CFAR Core Laboratories;4) To support the training and advancement of new investigators in HIV-related research;and 5) To provide community education regarding HIV and UMass CFAR Clinical HIV Research. The Clinical Core consists of a Clinical Sciences Core and a Clinical Immunology Core. The Clinical Sciences Core provides services that support the design, implementation, and analysis of patient-oriented and translational research with the goals of streamlining investigator training and protocol development. Other services provided by the Clinical Sciences Core include specimen receipt, processing, storage, and shipment;maintenance of extensive, integrated clinical (adult and pediatric) and laboratory databases;and a Bio-Statistics Sub-Core to provide statistical consultation for grant preparation, data analysis, and publications. The Clinical Immunology Core provides protocols, reagents, and services in support of patient-oriented and translational research. In addition, the UMass CFAR Clinical Core has recently partnered with the UMass Flow Cytometry Core to develop a Biosafety Level 3 Flow Cytometry and Sorting Facility. Over the next funding period, the Clinical Core will work with CFAR investigators and other CFAR Cores to provide services supporting studies that improve our understanding of HIV pathogenesis and strategies to prevent or treat HIV-1 infection.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
3P30AI042845-14S1
Application #
8440951
Study Section
Special Emphasis Panel (ZAI1-EC-A)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
14
Fiscal Year
2012
Total Cost
$227,956
Indirect Cost
$90,633
Name
University of Massachusetts Medical School Worcester
Department
Type
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Ambade, Aditya; Satishchandran, Abhishek; Szabo, Gyongyi (2016) Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1α activation. Sci Rep 6:21340
Musich, Thomas; O'Connell, Olivia; Gonzalez-Perez, Maria Paz et al. (2015) HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages. Retrovirology 12:25
Fouda, Genevieve G; Cunningham, Coleen K; McFarland, Elizabeth J et al. (2015) Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses. J Infect Dis 211:508-17
Gibson, Laura; Barysauskas, Constance M; McManus, Margaret et al. (2015) Reduced frequencies of polyfunctional CMV-specific T cell responses in infants with congenital CMV infection. J Clin Immunol 35:289-301
Greenough, Thomas C; Straubhaar, Juerg R; Kamga, Larisa et al. (2015) A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection. J Immunol 195:4185-97
Peters, Paul J; Gonzalez-Perez, Maria Paz; Musich, Thomas et al. (2015) Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes. Retrovirology 12:48
Luzuriaga, Katherine; Tabak, Barbara; Garber, Manuel et al. (2014) HIV type 1 (HIV-1) proviral reservoirs decay continuously under sustained virologic control in HIV-1-infected children who received early treatment. J Infect Dis 210:1529-38
Brehm, Michael A; Wiles, Michael V; Greiner, Dale L et al. (2014) Generation of improved humanized mouse models for human infectious diseases. J Immunol Methods 410:3-17
Ambade, Aditya; Catalano, Donna; Lim, Arlene et al. (2014) Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury. J Hepatol 61:903-11
Usami, Yoshiko; Göttlinger, Heinrich (2013) HIV-1 Nef responsiveness is determined by Env variable regions involved in trimer association and correlates with neutralization sensitivity. Cell Rep 5:802-12

Showing the most recent 10 out of 121 publications