The objective of the primate core is to provide the facility, materials and comprehensive clinical support necessary for the in vivo non-human primate studies of the CFAR investigators. This primate core provides up to 200 macaques, either rhesus or cynomolgus macaques. Virus studies using SIVmac251, SIVmac239, SIVs with deleted genes, pathogenic and non- pathogenic SHIV hybrid viruses are all too well with the expertise of the core. The Core leader, Preston A. Marx and Mr. Agegnehu Gettie, the core manager, have a decade of experience in using and developing primate retrovirus models. Dr. Marx has about 100 publications in simian models covering pathogenesis, vaccines and other topics. The studies to be carried out by the core include: 1. In vivo lymphocyte turnover, virus clearance and in vivo expression of HIV/SIV-co-receptors-David Ho group. 2. In vivo effects of passively administered neutralizing antibody and Mab on viral steady states, pathogenesis and prophylaxis-John Moore group. 3. Labeling to study the turnover of macrophages in infected and uninfected monkeys in vivo-Rhonda Kost group. 4. In vivo quasi-species and drug-resistance-Eric Delwart group. 5. Correlates of protection by SIV delta nef-Ruth Connor group and David Ho group. 6. Mucosal infection by macrophage tropic and T cell tropic SHIV-Cecelia Cheng-Mayer group. 7. Lipid-stabilized SIV antigen presentations-Leo Stamatatos group. 8. Study of species-specific viral tropism that map to regions of the viral genome outside of env-Jeremy Luban group. 9. Dendritic cell infections in vivo-Ralph Steinman and Melissa Pope groups.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Aaron Diamond AIDS Research Center
New York
United States
Zip Code
Mukhopadhyay, Madhura; Galperin, Moran; Patgaonkar, Mandar et al. (2017) DNA Vaccination by Electroporation Amplifies Broadly Cross-Restricted Public TCR Clonotypes Shared with HIV Controllers. J Immunol 199:3437-3452
Collins, Pamela Y; Kondos, Leeza; Pillai, Aravind et al. (2016) Passive Suicidal Ideation and Community Mental Health Resources in South Africa. Community Ment Health J 52:541-50
Markowitz, Martin; Evering, Teresa H; Garmon, Donald et al. (2014) A randomized open-label study of 3- versus 5-drug combination antiretroviral therapy in newly HIV-1-infected individuals. J Acquir Immune Defic Syndr 66:140-7
Mantell, Joanne E; West, Brooke S; Sue, Kimberly et al. (2011) Health care providers: a missing link in understanding acceptability of the female condom. AIDS Educ Prev 23:65-77
Hoffman, Susie; Higgins, Jenny A; Beckford-Jarrett, Sharlene T et al. (2011) Contexts of risk and networks of protection: NYC West Indian immigrants' perceptions of migration and vulnerability to sexually transmitted diseases. Cult Health Sex 13:513-28
Zhukovsky, Mikhail A; Basmaciogullari, Stéphane; Pacheco, Beatriz et al. (2010) Thermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes. PLoS One 5:e13249
Coovadia, Hoosen; Mantell, Joanne E (2010) Adolescents and HIV in sub-Saharan Africa: a timely issue and missed opportunity. Clin Infect Dis 51:852-4
Flacher, Vincent; Tripp, Christoph H; Stoitzner, Patrizia et al. (2010) Epidermal Langerhans cells rapidly capture and present antigens from C-type lectin-targeting antibodies deposited in the dermis. J Invest Dermatol 130:755-62
Yuan, Wen; Li, Xing; Kasterka, Marta et al. (2009) Oligomer-specific conformations of the human immunodeficiency virus (HIV-1) gp41 envelope glycoprotein ectodomain recognized by human monoclonal antibodies. AIDS Res Hum Retroviruses 25:319-28
Kassa, Aemro; Madani, Navid; Schön, Arne et al. (2009) Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain. J Virol 83:8364-78

Showing the most recent 10 out of 103 publications