The Retrovirology Services Core was established in 2002 and is co-directed by Drs. John Coffin and Bharat Ramratnam. The Core provides essential services to other CFAR cores in diagnosis and monitoring of HIV infection as well as specimen processing and archiving. The Core provides innovative tools for collaborative studies from its special interests in international HIV resistance monitoring, host factors influencing HIV natural history, using advances in stem cell biology to better understand HIV pathogenesis, and studies of immune activation. The Core will pursue four Specific Aims: (1) To provide essential viral assays and HIV monitoring methods, (2) To develop and support innovative retrovirology services along four thematic areas including a) developing and supporting assays for resistance monitoring and phylogenetics of HIV to characterize the molecular epidemiology of drug resistant HIV-1 transmission;b) identifying host factors that that correlate with HIV-1 burden in vivo using proteomic signatures in collaboration with Prevention Sciences Core;c) advancing our understanding of HIV-1 pathogenesis by modeling disease with induced pluripotent stem (iPS) cells in collaboration with the newly established Center for Stem Cell Biology, and d), quantifying levels of immune activation in collaboration with Nutrition, Metabolism and GI Core;(3) To provide training and mentorship to the local and international CFAR community and build technical capacity at international sites with a focus on non-clade-B transmission and drug resistance, and (4) To support the processing, archiving and distribution of virologic specimens. The Retrovirology core maintains the CFAR specimen repository and has >60,000 samples available for collaborative research with all CFAR sites. Services are prioritized to support CFAR developmental grant awardees and junior investigators.

Public Health Relevance

The Retrovirology Services Core provides basic laboratory services to HIV-1 investigators affiliated with the Lifespan/Tufts/Brown CFAR including tests of HIV levels and drug resistance for collaborative studies. The Core provides innovative methods to explore drug resistance and the way HIV causes disease. The Core has a large collection of >60,000 specimens available for research studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI042853-17
Application #
8685871
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
17
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Miriam Hospital
Department
Type
DUNS #
City
Providence
State
RI
Country
United States
Zip Code
02906
Merchant, R C; Clark, M A; Liu, T et al. (2017) Preferences for oral fluid rapid HIV self-testing among social media-using young black, Hispanic, and white men-who-have-sex-with-men (YMSM): implications for future interventions. Public Health 145:7-19
Clark, Uraina S; Sweet, Lawrence H; Morgello, Susan et al. (2017) High early life stress and aberrant amygdala activity: risk factors for elevated neuropsychiatric symptoms in HIV+ adults. Brain Imaging Behav 11:649-665
Barker, David H; Nugent, Nicole R; Delgado, Jeanne R et al. (2017) A genetic marker of risk in HIV-infected individuals with a history of hazardous drinking. AIDS Care 29:1186-1191
Javdani, Shabnam; Sadeh, Naomi; Donenberg, Geri R et al. (2017) Affect recognition among adolescents in therapeutic schools: relationships with posttraumatic stress disorder and conduct disorder symptoms. Child Adolesc Ment Health 22:42-48
Boyce, Ceejay L; Ganova-Raeva, Lilia; Archampong, Timothy N A et al. (2017) Identification and comparative analysis of hepatitis B virus genotype D/E recombinants in Africa. Virus Genes 53:538-547
Loeliger, Kelsey B; Biggs, Mary L; Young, Rebekah et al. (2017) Gender Differences in HIV Risk Behaviors Among Persons Involved in the U.S. Criminal Justice System and Living with HIV or at Risk for HIV: A ""Seek, Test, Treat, and Retain"" Harmonization Consortium. AIDS Behav 21:2945-2957
Youn, Bora; Shireman, Theresa I; Lee, Yoojin et al. (2017) Ten-year trends in antiretroviral therapy persistence among US Medicaid beneficiaries. AIDS 31:1697-1707
Grau, Lauretta E; Griffiths-Kundishora, Abbie; Heimer, Robert et al. (2017) Barriers and facilitators of the HIV care continuum in Southern New England for people with drug or alcohol use and living with HIV/AIDS: perspectives of HIV surveillance experts and service providers. Addict Sci Clin Pract 12:24
Phillips, Tamsin; Brittain, Kirsty; Mellins, Claude A et al. (2017) A Self-Reported Adherence Measure to Screen for Elevated HIV Viral Load in Pregnant and Postpartum Women on Antiretroviral Therapy. AIDS Behav 21:450-461
Duarte, Horacio A; Panpradist, Nuttada; Beck, Ingrid A et al. (2017) Current Status of Point-of-Care Testing for Human Immunodeficiency Virus Drug Resistance. J Infect Dis 216:S824-S828

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