This proposal is a competing renewal for the Penn Center for AIDS Research (CFAR), which includes the University of Pennsylvania, The Children's Hospital of Philadelphia and The Wistar Institute. This CFAR links faculty engaged in HIV/AIDS research at these institutions and is committed to goals laid out in the NIH CFAR mission statement and fostering interdisciplinary HIV/AIDS research activities on campus. The CFAR's Specific Aims are to: 1) provide leadership that creates and supports infrastructure for innovative, interdisciplinary, collaborative, and translational HIV/AIDS research on the CFAR campus;2) create, sponsor, and facilitate educational and training efforts that span scientifically diverse HIV/AIDS areas;3) conduct and coordinate community outreach efforts that communicate knowledge to and solicit input from domestic populations, particularly those hardest to reach and hardest hit by the HIV/AIDS epidemic in the Philadelphia area;4) develop partnerships with institutions and investigators outside the U.S. that strengthen the capacity for HIV/AIDS research, education, and training in developing countries most affected by the AIDS pandemic;and 5) promote collaborative research programs between CFARs that enhance and extend the added value that individual CFARs provide to the national CFAR network. The Penn CFAR includes four Scientific Programs: Virology/Pathogenesis, Clinical/Therapeutics, Immunology/Vaccine, and Behavioral &Social Sciences. The Center is directed by Dr. James A. Hoxie and co-directed by Dr. Ronald Collman and governed by an Executive Committee with input from an Internal Advisory Board and External Advisory Committee. The CFAR has a Developmental Core and seven Shared Resource Cores that provide key services to CFAR investigators not available elsewhere on campus including Clinical, Viral/Molecular, Immunology, Behavioral &Social Sciences, Biostatistics &Data Management, Non-Human Primate, and International. The Center remains committed to developing a creative, comprehensive, and interdisciplinary AIDS research program that is fully integrated with the research and educational mission of the University and dedicated to meeting the challenges of the AIDS pandemic.

Public Health Relevance

This renewal of the NIH Center will build on the successes and strengths of the Penn CFAR's first nine years and continue to provide unique and proactive leadership, contribute to an extraordinary environment for conducting interdisciplinary HIV/AIDS science, and foster collegial and collaborative relationships among its investigators. It is critical that the challenges of AIDS be met through approaches the CFAR will take.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI045008-13
Application #
8104260
Study Section
Special Emphasis Panel (ZAI1-SV-A (J3))
Program Officer
Namkung, Ann S
Project Start
1999-07-15
Project End
2014-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
13
Fiscal Year
2011
Total Cost
$2,916,583
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Frye, Margaret; Chae, Sophia (2017) Physical attractiveness and women's HIV risk in rural Malawi. Demogr Res 37:251-294
Reid, Michael J A; Steenhoff, Andrew P; Mannathoko, Naledi et al. (2017) Staphylococcus aureus nasal colonization among HIV-infected adults in Botswana: prevalence and risk factors. AIDS Care 29:961-965
Koenig, H C; Mounzer, K; Daughtridge, G W et al. (2017) Urine assay for tenofovir to monitor adherence in real time to tenofovir disoproxil fumarate/emtricitabine as pre-exposure prophylaxis. HIV Med 18:412-418
Kelly, Matthew S; Surette, Michael G; Smieja, Marek et al. (2017) The Nasopharyngeal Microbiota of Children With Respiratory Infections in Botswana. Pediatr Infect Dis J 36:e211-e218
Kim, Dorothy; Hofstaedter, Casey E; Zhao, Chunyu et al. (2017) Optimizing methods and dodging pitfalls in microbiome research. Microbiome 5:52
Wood, Sarah M; Lee, Susan; Barg, Frances K et al. (2017) Young Transgender Women's Attitudes Toward HIV Pre-exposure Prophylaxis. J Adolesc Health 60:549-555
Pardi, Norbert; Secreto, Anthony J; Shan, Xiaochuan et al. (2017) Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge. Nat Commun 8:14630
Kohler, Iliana V; Payne, Collin F; Bandawe, Chiwoza et al. (2017) The Demography of Mental Health Among Mature Adults in a Low-Income, High-HIV-Prevalence Context. Demography 54:1529-1558
Li, Shuying S; Kochar, Nidhi K; Elizaga, Marnie et al. (2017) DNA Priming Increases Frequency of T-Cell Responses to a Vesicular Stomatitis Virus HIV Vaccine with Specific Enhancement of CD8+ T-Cell Responses by Interleukin-12 Plasmid DNA. Clin Vaccine Immunol 24:
Wetzel, Katherine S; Yi, Yanjie; Elliott, Sarah T C et al. (2017) CXCR6-Mediated Simian Immunodeficiency Virus SIVagmSab Entry into Sabaeus African Green Monkey Lymphocytes Implicates Widespread Use of Non-CCR5 Pathways in Natural Host Infections. J Virol 91:

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