This proposal is a competing renewal for the Penn Center for AIDS Research (CFAR), which includes the University of Pennsylvania, The Children's Hospital of Philadelphia and The Wistar Institute. This CFAR links faculty engaged in HIV/AIDS research at these institutions and is committed to goals laid out in the NIH CFAR mission statement and fostering interdisciplinary HIV/AIDS research activities on campus. The CFAR's Specific Aims are to: 1) provide leadership that creates and supports infrastructure for innovative, interdisciplinary, collaborative, and translational HIV/AIDS research on the CFAR campus;2) create, sponsor, and facilitate educational and training efforts that span scientifically diverse HIV/AIDS areas;3) conduct and coordinate community outreach efforts that communicate knowledge to and solicit input from domestic populations, particularly those hardest to reach and hardest hit by the HIV/AIDS epidemic in the Philadelphia area;4) develop partnerships with institutions and investigators outside the U.S. that strengthen the capacity for HIV/AIDS research, education, and training in developing countries most affected by the AIDS pandemic;and 5) promote collaborative research programs between CFARs that enhance and extend the added value that individual CFARs provide to the national CFAR network. The Penn CFAR includes four Scientific Programs: Virology/Pathogenesis, Clinical/Therapeutics, Immunology/Vaccine, and Behavioral &Social Sciences. The Center is directed by Dr. James A. Hoxie and co-directed by Dr. Ronald Collman and governed by an Executive Committee with input from an Internal Advisory Board and External Advisory Committee. The CFAR has a Developmental Core and seven Shared Resource Cores that provide key services to CFAR investigators not available elsewhere on campus including Clinical, Viral/Molecular, Immunology, Behavioral &Social Sciences, Biostatistics &Data Management, Non-Human Primate, and International. The Center remains committed to developing a creative, comprehensive, and interdisciplinary AIDS research program that is fully integrated with the research and educational mission of the University and dedicated to meeting the challenges of the AIDS pandemic.

Public Health Relevance

This renewal of the NIH Center will build on the successes and strengths of the Penn CFAR's first nine years and continue to provide unique and proactive leadership, contribute to an extraordinary environment for conducting interdisciplinary HIV/AIDS science, and foster collegial and collaborative relationships among its investigators. It is critical that the challenges of AIDS be met through approaches the CFAR will take.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI045008-14
Application #
8293251
Study Section
Special Emphasis Panel (ZAI1-SV-A (J3))
Program Officer
Namkung, Ann S
Project Start
1999-07-15
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
14
Fiscal Year
2012
Total Cost
$3,047,509
Indirect Cost
$950,924
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Gross, Robert; Bandason, Tsitsi; Langhaug, Lisa et al. (2015) Factors associated with self-reported adherence among adolescents on antiretroviral therapy in Zimbabwe. AIDS Care 27:322-6
Safren, Steven A; Biello, Katie B; Smeaton, Laura et al. (2014) Psychosocial predictors of non-adherence and treatment failure in a large scale multi-national trial of antiretroviral therapy for HIV: data from the ACTG A5175/PEARLS trial. PLoS One 9:e104178
Muluneh, Melaku; Shang, Wu; Issadore, David (2014) Track-etched magnetic micropores for immunomagnetic isolation of pathogens. Adv Healthc Mater 3:1078-85
Wohl, David A; Arnoczy, Gretchen; Fichtenbaum, Carl J et al. (2014) Comparison of cardiovascular disease risk markers in HIV-infected patients receiving abacavir and tenofovir: the nucleoside inflammation, coagulation and endothelial function (NICE) study. Antivir Ther 19:141-7
Nachega, Jean B; Parienti, Jean-Jacques; Uthman, Olalekan A et al. (2014) Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: A meta-analysis of randomized controlled trials. Clin Infect Dis 58:1297-307
Zetola, Nicola M; Modongo, Chawangwa; Olabiyi, Bisayo et al. (2014) Examining the relationship between alcohol use and high-risk sex practices in a population of women with high HIV incidence despite high levels of HIV-related knowledge. Sex Transm Infect 90:216-22
Haas, David W; Kwara, Awewura; Richardson, Danielle M et al. (2014) Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes. J Antimicrob Chemother 69:2175-82
Ramirez, Lorenzo A; Daniel, Alexander; Frank, Ian et al. (2014) Seroprotection of HIV-infected subjects after influenza A(H1N1) vaccination is directly associated with baseline frequency of naive T cells. J Infect Dis 210:646-50
Liu, Weimin; Li, Yingying; Shaw, Katharina S et al. (2014) African origin of the malaria parasite Plasmodium vivax. Nat Commun 5:3346
Blank, Michael B; Hennessy, Michael; Eisenberg, Marlene M (2014) Increasing quality of life and reducing HIV burden: the PATH+ intervention. AIDS Behav 18:716-25

Showing the most recent 10 out of 235 publications