This proposal is a competing renewal for the Penn Center for AIDS Research (CFAR), which includes the University of Pennsylvania, The Children's Hospital of Philadelphia, and The Wistar Institute. The Penn CFAR links HIV/AIDS investigators at these institutions and is committed to goals laid out in the NIH CFAR mission statement and fostering interdisciplinary HIV/AIDS research activities on the Penn/CHOP/Wistar campus. The CFAR's Specific Aims are to: (1) provide leadership that creates and supports infrastructure for innovative, interdisciplinary, collaborative, and translational HIV/AIDS research: (2) identify new areas of scientific opportunity in HIV/AIDS research;(3) create, sponsor and facilitate educational and training programs across diverse scientific areas and play a leadership role in mentoring the next generation of HIV/AIDS investigators;(4) conduct and coordinate community outreach efforts: (5) promote collaborative and synergistic activities and research programs between CFARs that extend the added value of individual CFARs;and (6) develop partnerships with institutions and investigators outside the U.S. that strengthen capacity for HIV/AIDS research and mentoring in developing countries and resource limited settings most affected by the AIDS pandemic. The Penn CFAR includes four Research Areas: Virology/ Pathogenesis, Clinical/Therapeutics, Immunology/Vaccine, and Behavioral &Social Sciences, and has created three forward-looking and dynamic Scientific Working Groups to meet key emerging scientific priorities and opportunities in HIV/AIDS research. The Center is directed by Dr. James Hoxie, co-directed by Dr. Ronald Collman and governed by an Executive Committee with input from an Internal Advisory Board and External Advisory Committee. The CFAR has a Developmental Core and seven Shared Resource Cores: Clinical, Viral/Molecular, Immunology, Behavioral &Social Sciences, Biostatistics &Data Management. Nonhuman Primate, and International. These Cores provide unique services for HIV/AIDS research that are not available elsewhere on campus, leadership and education. The Center remains committed to developing a creative, comprehensive, and interdisciplinary AIDS research program that is fully integrated with the research and educational missions of Penn, CHOP and Wistar and dedicated to meeting the ongoing challenges of the AIDS pandemic.
This CFAR will build on the success and strengths of its three previous funding cycles to 1) provide strong, experienced, and proactive leadership;2) contribute to a rich environment of interdisciplinary HIV/AIDS science;3) develop and lead new initiatives in cutting-edge areas that address the NIH Strategic Plan for HIV research;and 4) foster collegial and collaborative relationships among its investigators.
|Gross, Robert; Bandason, Tsitsi; Langhaug, Lisa et al. (2015) Factors associated with self-reported adherence among adolescents on antiretroviral therapy in Zimbabwe. AIDS Care 27:322-6|
|Safren, Steven A; Biello, Katie B; Smeaton, Laura et al. (2014) Psychosocial predictors of non-adherence and treatment failure in a large scale multi-national trial of antiretroviral therapy for HIV: data from the ACTG A5175/PEARLS trial. PLoS One 9:e104178|
|Muluneh, Melaku; Shang, Wu; Issadore, David (2014) Track-etched magnetic micropores for immunomagnetic isolation of pathogens. Adv Healthc Mater 3:1078-85|
|Wohl, David A; Arnoczy, Gretchen; Fichtenbaum, Carl J et al. (2014) Comparison of cardiovascular disease risk markers in HIV-infected patients receiving abacavir and tenofovir: the nucleoside inflammation, coagulation and endothelial function (NICE) study. Antivir Ther 19:141-7|
|Nachega, Jean B; Parienti, Jean-Jacques; Uthman, Olalekan A et al. (2014) Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: A meta-analysis of randomized controlled trials. Clin Infect Dis 58:1297-307|
|Zetola, Nicola M; Modongo, Chawangwa; Olabiyi, Bisayo et al. (2014) Examining the relationship between alcohol use and high-risk sex practices in a population of women with high HIV incidence despite high levels of HIV-related knowledge. Sex Transm Infect 90:216-22|
|Haas, David W; Kwara, Awewura; Richardson, Danielle M et al. (2014) Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes. J Antimicrob Chemother 69:2175-82|
|Ramirez, Lorenzo A; Daniel, Alexander; Frank, Ian et al. (2014) Seroprotection of HIV-infected subjects after influenza A(H1N1) vaccination is directly associated with baseline frequency of naive T cells. J Infect Dis 210:646-50|
|Liu, Weimin; Li, Yingying; Shaw, Katharina S et al. (2014) African origin of the malaria parasite Plasmodium vivax. Nat Commun 5:3346|
|Blank, Michael B; Hennessy, Michael; Eisenberg, Marlene M (2014) Increasing quality of life and reducing HIV burden: the PATH+ intervention. AIDS Behav 18:716-25|
Showing the most recent 10 out of 235 publications