; The mission ofthe Nonhuman Primate (NHP) Core (Core H), located at the Tulane National Primate Research Center (TNPRC), is to provide to Penn CFAR investigators highly integrated clinical and laboratory resources and expertise in using NHP models relevant to AIDS. The Core is lead by Andrew Lackner with Preston Marx, Ronald Veazey, and Marcelo Kuroda as additional key personnel. Core H adds value to the CFAR by enhancing and facilitating the ability of CFAR investigators to perform HIV/SIV-related studies in NHPs, providing mentorship and on-site training to junior investigators, and promoting scientific collaborations between the TNPRC and CFAR investigators. Specific goals are to (1) provide oversight and assistance in all phases of research using NHPs, supporting CFAR investigator projects and proposals and providing resources, assistance with experimental design, and compliance with all animal welfare and biosafety requirements;(2) provide housing, clinical care, animal husbandry, and other routine and necessary services for NHPs assigned to CFAR projects;(3) provide technical expertise and laboratory support for studies utilizing NHPs;(4) support a NHP Pilot Grants Program (separate from but complementary to the Developmental Pilot Program run by Core B) designed to encourage junior and new investigators to use NHP models;(5) provide education, training and mentoring to junior and new investigators who have not previously worked with NHP;and (6) stimulate and facilitate translation of bench-based findings to NHP experimentation. Collaborations between Core H and the CFAR are facilitated by jointly sponsored symposia focused on NHP HIV/SIV research and a seminar series integrated with TNPRC via video-conference links. Core H includes specialized clinical, laboratory and consultative components. The Core performs a variety of specialized services including in situ hybridization, immunohistochemistry, confocal microscopy and image analysis. Core H also participates in the CFAR's mentoring mission by training and educating CFAR members and their students and postdocs on use of NHP models. Core performance is evaluated as part ofthe CFAR's annual strategic planning process. Core H will also play an active role in working with the CFAR's newly formed scientific working groups. In the current cycle Core H has supported 12 NHP Pilot Projects, closely worked with 20 CFAR investigators, provided onsite training for 6 students and/or post docs, and contributed to 20 publications, and 8 NIH grants.

Public Health Relevance

A Nonhuman Primate Core is unique among CFARs and for Penn CFAR investigators provides extraordinary opportunities for research. As in the last 10 years, the availability of specialized resources and expertise will enhance the research mission ofthe Penn CFAR, result in new collaborations and mentoring relationships, and introduce to investigators the benefits and utility of using NHP as a translational bridge between in vitro and small animal models and studies in humans.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
United States
Zip Code
Moeller, Andrew H; Caro-Quintero, Alejandro; Mjungu, Deus et al. (2016) Cospeciation of gut microbiota with hominids. Science 353:380-2
Jacobson, Jeffrey M; Zheng, Lu; Wilson, Cara C et al. (2016) The Safety and Immunogenicity of an Interleukin-12-Enhanced Multiantigen DNA Vaccine Delivered by Electroporation for the Treatment of HIV-1 Infection. J Acquir Immune Defic Syndr 71:163-71
Enane, Leslie A; Gastañaduy, Paul A; Goldfarb, David M et al. (2016) Impact of Rotavirus Vaccination on Hospitalizations and Deaths From Childhood Gastroenteritis in Botswana. Clin Infect Dis 62 Suppl 2:S168-74
Fedor, Theresa M; Kohler, Hans-Peter; McMahon, James M (2016) Changing attitudes and beliefs towards a woman's right to protect against HIV risk in Malawi. Cult Health Sex 18:435-52
Musselwhite, Laura W; Andrade, Bruno B; Ellenberg, Susan S et al. (2016) Vitamin D, D-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study. EBioMedicine 4:115-23
Dowshen, Nadia; Matone, Meredith; Luan, Xianqun et al. (2016) Behavioral and Health Outcomes for HIV+ Young Transgender Women (YTW) Linked To and Engaged in Medical Care. LGBT Health 3:162-7
Motshoge, Thato; Tawe, Leabaneng; Muthoga, Charles Waithaka et al. (2016) Cytochrome P450 2C8*2 allele in Botswana: Human genetic diversity and public health implications. Acta Trop 157:54-8
Liu, Weimin; Sundararaman, Sesh A; Loy, Dorothy E et al. (2016) Multigenomic Delineation of Plasmodium Species of the Laverania Subgenus Infecting Wild-Living Chimpanzees and Gorillas. Genome Biol Evol 8:1929-39
Song, Jinzhao; Mauk, Michael G; Hackett, Brent A et al. (2016) Instrument-Free Point-of-Care Molecular Detection of Zika Virus. Anal Chem 88:7289-94
Chehoud, Christel; Dryga, Anatoly; Hwang, Young et al. (2016) Transfer of Viral Communities between Human Individuals during Fecal Microbiota Transplantation. MBio 7:e00322

Showing the most recent 10 out of 551 publications