The overarching aim of the Virology Core is to provide key infrastructure support to the basic, translational, and clinical research capacity of the Emory/Atlanta community in the fields of HIV infection and AIDS. This goal is achieved by providing state-of-the-art technology and resources for all relevant clinical and preventive studies of human subjects (Clinical component) and SIV/SHIV-infected non-human primates (Pre-Clinical component). In addition, the Core provides key leadership in this research area through collaboration, training, and mentoring. The overall goal of the Core will be accomplished through the following Specific Aims: 1. To expand the range of existing assays for quantification of all aspects of SIV/SHIV infection and replication that are essential to the study of AIDS pathogenesis, therapy, and prevention in non-human primates. 2. To expand the menu of tests needed to support clinical studies/trials of HIV-1 infections and co-infections, provide testing in a CLIA certified laboratory, and provide economy of scale through provision of shared resources. 3. To provide technical and intellectual support, including consultation and training opportunities, to local, national, and international AIDS research efforts that include both non-human primates and human infections. 4. To facilitate academic and industrial development of novel AIDS therapy and prevention programs through provision of virological services. The Emory CFAR Virology Core will continue to provide crucial support for the HIV/AIDS research programs by establishment of a world-class, highly recognized service laboratory that offers a broad repertoire of cutting edge virological and gene expression assays.
Through the provision of viral quantification and gene expression services, the Virology Core will play a crucial role in the fight to prevent infection, treat those living with AIDS and ultimately eradicate HIV/AIDS. The numerous research projects that the Core supports will be instrumental in developing a preventive vaccine, discovering new novel therapeutics, and understanding the mechanisms of AIDS pathogenesis.
|Mustanski, Brian; Parsons, Jeffrey T; Sullivan, Patrick S et al. (2018) Biomedical and Behavioral Outcomes of Keep It Up!: An eHealth HIV Prevention Program RCT. Am J Prev Med 55:151-158|
|Martin, Maureen P; Naranbhai, Vivek; Shea, Patrick R et al. (2018) Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. J Clin Invest 128:1903-1912|
|Sam, Soya S; Caliendo, Angela M; Ingersoll, Jessica et al. (2018) Evaluation of Performance Characteristics of Panther Fusion Assays for Detection of Respiratory Viruses from Nasopharyngeal and Lower Respiratory Tract Specimens. J Clin Microbiol 56:|
|Jenness, Samuel M; Goodreau, Steven M; Morris, Martina (2018) EpiModel: An R Package for Mathematical Modeling of Infectious Disease over Networks. J Stat Softw 84:|
|Eckard, Allison Ross; Raggi, Paolo; O'Riordan, Mary Ann et al. (2018) Effects of vitamin D supplementation on carotid intima-media thickness in HIV-infected youth. Virulence 9:294-305|
|Singleton, Robyn; Winskell, Kate; McLeod, Haley et al. (2018) Young Africans' social representations of sexual abuse of power in their HIV-related creative narratives, 2005-2014: cultural scripts and applied possibilities. Cult Health Sex :1-16|
|Hussen, Sophia A; Easley, Kirk A; Smith, Justin C et al. (2018) Social Capital, Depressive Symptoms, and HIV Viral Suppression Among Young Black, Gay, Bisexual and Other Men Who Have Sex with Men Living with HIV. AIDS Behav 22:3024-3032|
|Lahiri, Cecile D; Brown, Nakita L; Ryan, Kevin J et al. (2018) HIV RNA persists in rectal tissue despite rapid plasma virologic suppression with dolutegravir-based therapy. AIDS 32:2151-2159|
|Halpin, Sean N; Carruth, Edwin Clayton; Rai, Ramona P et al. (2018) Complementary and Alternative Medicine Among Persons living with HIV in the Era of Combined Antiretroviral Treatment. AIDS Behav 22:848-852|
|Holloway, Ian W; Bednarczyk, Robert; Fenimore, Vincent L et al. (2018) Factors Associated with Immunization Opinion Leadership among Men Who Have Sex with Men in Los Angeles, California. Int J Environ Res Public Health 15:|
Showing the most recent 10 out of 1005 publications