The long term goals of the Developmental Core are to solicit and provide funding for novel research projects focusing on HIV from our three member institutions (FHl, RTI, UNC) as well as Historically Black Colleges and Universities (HBCUs) throughout North Carolina and international partners working with UNC, RTI, and FHl. We will conduct objective peer review and assign senior investigators as mentors to nurture the research and subsequent publication and grant submission. In the first year ofthe new grant cycle we will combine $150,000 of CFAR funds with $75,000 of UNC funds to support small ($5,000-$20,000) awards in all aspects of HIV research (basic and clinical sciences, translational research, epidemiology, vaccinology, and behavioral research). Promising minority, female and junior investigators will be identified and mentored until they have successful independent careers, including external funding. We will continue to focus on the ongoing epidemic in women, minorities and international communities. We will also make larger awards (up to $50,000) in two settings: collaborative multidisciplinary efforts that originate in one of the Working Groups, which include the four CFAR initiatives;and in collaboration with the Developmental Core of the CTSA in which the larger award is made but the costs are shared with the CFAR and in some cases also the sponsoring Department, thus leveraging CFAR funding 2-4 fold. Outreach and education will be accomplished through: 1) presentation by all awardees at our weekly ID/CFAR conference, 2) our annual HIV Update course for 500 clinicians from the Southeast, 3) presentation of posters by awardees at the HIV Update and World AIDS Day, and 4) Research Dissemination Meetings in South Africa and Malawi. Continuous quality improvement will remain a focus consisting of a review of the entire process including solicitation, review, mentoring and productivity of awardees.

Public Health Relevance

The Developmental Core provides funding to support new research and new researchers in the context of a large supportive research environment. These small awards impact research both domestically and internationally. The goal of this core is encourage a dynamic and risk-taking research environment that can lead to new lines of research with the long term goal of impacting the HIV epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI050410-16
Application #
8531832
Study Section
Special Emphasis Panel (ZAI1-ELB-A)
Project Start
2013-08-01
Project End
2016-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
16
Fiscal Year
2013
Total Cost
$269,478
Indirect Cost
$74,886
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Rutstein, S E; Golin, C E; Wheeler, S B et al. (2016) On the front line of HIV virological monitoring: barriers and facilitators from a provider perspective in resource-limited settings. AIDS Care 28:1-10
Cottrell, Mackenzie L; Yang, Kuo H; Prince, Heather M A et al. (2016) A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine. J Infect Dis 214:55-64
Sin, Sang-Hoon; Kang, Sun Ah; Kim, Yongbaek et al. (2016) Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Compensates for Interleukin-6 in Initial B Cell Activation. J Virol 90:2150-4
Chen, J; Malone, S; Prince, H M A et al. (2016) Model-Based Analysis of Unbound Lopinavir Pharmacokinetics in HIV-Infected Pregnant Women Supports Standard Dosing in the Third Trimester. CPT Pharmacometrics Syst Pharmacol 5:147-57
Davis, Nicole L; Miller, William C; Hudgens, Michael G et al. (2016) Maternal and Breastmilk Viral Load: Impacts of Adherence on Peripartum HIV Infections Averted-The Breastfeeding, Antiretrovirals, and Nutrition Study. J Acquir Immune Defic Syndr 73:572-580
Davis, Alissa; Meyerson, Beth E; Aghaulor, Blessing et al. (2016) Barriers to health service access among female migrant Ugandan sex workers in Guangzhou, China. Int J Equity Health 15:170
O'Donnell, Julie K; Gaynes, Bradley N; Cole, Stephen R et al. (2016) Ongoing life stressors and suicidal ideation among HIV-infected adults with depression. J Affect Disord 190:322-8
Cottrell, Mackenzie L; Prince, Heather M A; Allmon, Andrew et al. (2016) Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design. J Acquir Immune Defic Syndr 72:498-506
Lancaster, Kathryn E; Go, Vivian F; Lungu, Thandie et al. (2016) Substance use and HIV infection awareness among HIV-infected female sex workers in Lilongwe, Malawi. Int J Drug Policy 30:124-31
Barlow-Mosha, Linda; Angelidou, Konstantia; Lindsey, Jane et al. (2016) Nevirapine- Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy in HIV-Infected Infants and Young Children: Long-term Follow-up of the IMPAACT P1060 Randomized Trial. Clin Infect Dis 63:1113-21

Showing the most recent 10 out of 1330 publications