The broad, long-term objectives of the Biostatistics Core (Core F) are to provide a full spectrum of statistical consulting services for HIV/AIDS-related research ofthe UNC CFAR.
The specific aims i nclude (1) providing a full spectrum of collaborative biostatistical services, (2) serving as a liaison between AIDS researchers and statistical scientists within the UNC CFAR research community and beyond, (3) providing scientific leadership, (4) providing biostatistical training and education to the UNC CFAR research community, and (5) engaging in evaluation and strategic planning to address the changing needs ofthe UNC CFAR. To achieve these aims, members of Core F proactively engage UNC CFAR investigators to identify and deliver services essential for highly productive design, management, analysis and publication ofAIDS research. Core F contributes to the framing of hypotheses, development of study designs, preparation of grant applications, selection of best statistical strategies, and delivery of statistical analyses required for publications. Investigators new to AIDS research receive highest priority. Core F also serves as a nexus between statistical and biomedical scientists in HIV research. Through the Core, clinicians are linked to statistical coinvestigators, while statisticians initiating AIDS-related methods research are connected with clinical coinvestigators. Organization as a formal Biostatistics Cpre greatly enhances the efficiency and ability of the Core to connect communities of scientists and to provide mentoring and training in statistics to AIDS researchers. Strong institutional support from the Department of Biostatistics allows Core F to take full advantage of existing infrastructure, resources and contacts with faculty renowned for their expertise in specialized fields of statistics. The Core proactively seeks Biostatistics faculty and students interested in participating as new members of Core F.

Public Health Relevance

Consistent with the mission ofthe NIH CFAR Program, the Biostatistics Core delivers essential biostatistical support and expertise to HIV/AIDS investigators ofthe UNC CFAR. These collaborative contributions ensure investigators make measurements, inferences, and predictions that are accurate, precise, and relevant to their particular research goals.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Special Emphasis Panel (ZAI1-ELB-A)
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University of North Carolina Chapel Hill
Chapel Hill
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Sin, Sang-Hoon; Kang, Sun Ah; Kim, Yongbaek et al. (2016) Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Compensates for Interleukin-6 in Initial B Cell Activation. J Virol 90:2150-4
Rutstein, S E; Golin, C E; Wheeler, S B et al. (2016) On the front line of HIV virological monitoring: barriers and facilitators from a provider perspective in resource-limited settings. AIDS Care 28:1-10
Cottrell, Mackenzie L; Yang, Kuo H; Prince, Heather M A et al. (2016) A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine. J Infect Dis 214:55-64
Davis, Alissa; Meyerson, Beth E; Aghaulor, Blessing et al. (2016) Barriers to health service access among female migrant Ugandan sex workers in Guangzhou, China. Int J Equity Health 15:170
Chen, J; Malone, S; Prince, H M A et al. (2016) Model-Based Analysis of Unbound Lopinavir Pharmacokinetics in HIV-Infected Pregnant Women Supports Standard Dosing in the Third Trimester. CPT Pharmacometrics Syst Pharmacol 5:147-57
Davis, Nicole L; Miller, William C; Hudgens, Michael G et al. (2016) Maternal and Breastmilk Viral Load: Impacts of Adherence on Peripartum HIV Infections Averted-The Breastfeeding, Antiretrovirals, and Nutrition Study. J Acquir Immune Defic Syndr 73:572-580
Lancaster, Kathryn E; Go, Vivian F; Lungu, Thandie et al. (2016) Substance use and HIV infection awareness among HIV-infected female sex workers in Lilongwe, Malawi. Int J Drug Policy 30:124-31
O'Donnell, Julie K; Gaynes, Bradley N; Cole, Stephen R et al. (2016) Ongoing life stressors and suicidal ideation among HIV-infected adults with depression. J Affect Disord 190:322-8
Cottrell, Mackenzie L; Prince, Heather M A; Allmon, Andrew et al. (2016) Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design. J Acquir Immune Defic Syndr 72:498-506
Althoff, Keri N; Rebeiro, Peter F; Hanna, David B et al. (2016) A picture is worth a thousand words: maps of HIV indicators to inform research, programs, and policy from NA-ACCORD and CCASAnet clinical cohorts. J Int AIDS Soc 19:20707

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