Since the beginning of the AIDS epidemic, the Bronx has been one of the epicenters of HIV infection within the United States. The Einstein/Montefiore Medical Center (MMC) CFAR serves the Bronx, a borough of New York City that remains at the leading edge of the AIDS epidemic. The 20,627 known individuals living with HIV/AIDS in the Bronx represent 2.6% of the estimated national caseload. Investigators at Einstein and MMC have developed a broad-based research effort that is examining multiple and diverse aspects of the basic science, clinical manifestations, behavioral aspects and epidemiology of HIV and HIV-related diseases. The AIDS research effort at Einstein and MMC is led by over 70 principal investigators who are supported by greater than 25 million dollars of annual funding from the NIH. The leadership and infrastructure provided by the Einstein/MMC CFAR has been extremely successful in incorporating the diverse AIDS investigative effort at Einstein/MMC into a unified and highly interactive Program. During the past four years of NIH funding, the Einstein/MMC CFAR has been extremely successful in implementing its proposed Specific Aims and markedly increasing collaborative research projects among Einstein basic investigators and MMC clinical investigators, establishing well-run and highly-used Core facilities and providing intellectual, scientific, technical and financial help to foster and nurture the careers of junior AIDS investigators. Through internal and external recruitment, the CFAR has increased the number of investigators involved in AIDS-related research from 38 to 72. During this time, CFAR investigators have published over 700 papers almost 10% of which specifically acknowledge support from the CFAR. The CFAR has dramatically increased institutional support for AIDS-related research at Einstein, which has contributed almost 3.4 million dollars to recruit CFAR investigators, subsidize CFAR cores, renovate CFAR Core space and purchase equipment to expand CFAR Core services. In addition, the administration has committed another one million dollars to recruit additional AIDS researchers to Einstein. We have engaged in detailed Strategic Planning sessions using SWOT analysis to address our weaknesses and leverage our strengths into new areas. A major accomplishment that is directly attributed to this process is the dramatic expansion of our international AIDS research programs in developing countries. Four years ago we had no active International AIDS research programs. We now have active programs in South Africa, Rwanda, Ethiopia, India, Bangladesh and Guatemala. These and other accomplishments and scientific advances made by Einstein/MMC CFAR investigators during this funding period represent a very high level of value-added benefit from the Einstein/MMC CFAR.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-EC-A (J1))
Program Officer
Namkung, Ann S
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Albert Einstein College of Medicine
Schools of Medicine
United States
Zip Code
Rao, Vasudev R; Neogi, Ujjwal; Eugenin, Eliseo et al. (2014) The gp120 protein is a second determinant of decreased neurovirulence of Indian HIV-1C isolates compared to southern African HIV-1C isolates. PLoS One 9:e107074
Singh, M; Quispe-Tintaya, W; Chandra, D et al. (2014) Direct incorporation of the NKT-cell activator ?-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy. Br J Cancer 111:1945-54
Jelen, Mateja M; Chen, Zigui; Kocjan, Boštjan J et al. (2014) Global genomic diversity of human papillomavirus 6 based on 724 isolates and 190 complete genome sequences. J Virol 88:7307-16
Tarassishin, Leonid; Suh, Hyeon-Sook; Lee, Sunhee C (2014) LPS and IL-1 differentially activate mouse and human astrocytes: role of CD14. Glia 62:999-1013
Strickler, Howard D; Martinson, Jeffrey; Desai, Seema et al. (2014) The relation of plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) with HPV persistence in HIV-infected and HIV-uninfected women. Viral Immunol 27:20-5
Tarassishin, Leonid; Casper, Diana; Lee, Sunhee C (2014) Aberrant expression of interleukin-1? and inflammasome activation in human malignant gliomas. PLoS One 9:e103432
Prados-Rosales, Rafael; Carreño, Leandro J; Batista-Gonzalez, Ana et al. (2014) Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosis. MBio 5:e01921-14
Stec, Jozef; Vilchèze, Catherine; Lun, Shichun et al. (2014) Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis. ChemMedChem 9:2528-37
Benning, Lorie; Golub, Elizabeth T; Anastos, Kathryn et al. (2014) Comparison of lower genital tract microbiota in HIV-infected and uninfected women from Rwanda and the US. PLoS One 9:e96844
Shuter, Jonathan; Moadel, Alyson B; Kim, Ryung S et al. (2014) Self-efficacy to quit in HIV-infected smokers. Nicotine Tob Res 16:1527-31

Showing the most recent 10 out of 381 publications