One of the greatest added values of the HU CFAR has been accelerated member access to new and emerging technologies. In the previous two competing submissions, these technologies have been largely provided through the Molecular Biology &Genomics Core and the Immunology Core. Services provided have focused largely on genomic and flow cytometic technologies, and have evolved over time, continuing to provide members with support that would be otherwise inaccessible to individual investigators. Based on our 2012 CFAR Strategic Review, the membership concluded that by integrating these cores and focusing on the intersection of advanced immunologic and genomic technologies and the increasing computational challenges associated with these, we could better leverage CFAR resources to serve members. These two cores were thus merged and redefined to form a single Advanced Technologies Core (ATC). The overall mission of the new Advanced Technologies Core is to provide access to advanced cytometric/genomic technologies and the computational methodologies that are an increasingly challenging barrier to individual investigators. At the current time, much of the identified need for members is in the capture of information regarding the phenotypic and functional state of individual cells, indexing these samples, and then capitalizing on this precious biomaterial to develop a comprehensive picture of the genomic landscape that exists in particular disease states. To ensure that all Harvard CFAR laboratories have access to this remarkable analytical power, this core will facilitate access to such technologies through the following aims: 1) Provide CFAR member access to state-of-the art technologies. 2) Providing user training in the above technologies, as well as computational assistance. 3) Building a virtual community using state of the art sharing and distribution tools.

Public Health Relevance

A significant technology-driven revolution has occurred in the development of new flow cytometry, imaging and genomic technologies, that is critical to studies of virus-host interactions, therapeutic and prevention interventions, and vaccine development activities,-and the ATC aims to provide access to these advanced technologies and associated computational methodologies to the Harvard CFAR community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI060354-11
Application #
8697498
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Harvard Medical School
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02138
Hyle, Emily P; Mayosi, Bongani M; Middelkoop, Keren et al. (2017) The association between HIV and atherosclerotic cardiovascular disease in sub-Saharan Africa: a systematic review. BMC Public Health 17:954
Luckow, Peter W; Kenny, Avi; White, Emily et al. (2017) Implementation research on community health workers' provision of maternal and child health services in rural Liberia. Bull World Health Organ 95:113-120
McCluskey, Suzanne M; Boum 2nd, Yap; Musinguzi, Nicholas et al. (2017) Brief Report: Appraising Viral Load Thresholds and Adherence Support Recommendations in the World Health Organization Guidelines for Detection and Management of Virologic Failure. J Acquir Immune Defic Syndr 76:183-187
Viganò, Selena; Negrón, Jordi J; Tse, Samantha et al. (2017) HLA-G+ HIV-1-specific CD8+ T cells are associated with HIV-1 immune control. AIDS 31:207-212
Brown, Danielle N; Langan, Sinéad M; Freeman, Esther E (2017) Task Shifting in Dermatology: A Call to Action. JAMA Dermatol 153:1179-1180
Calabrese, Sarah K; Underhill, Kristen; Mayer, Kenneth H (2017) HIV Preexposure Prophylaxis and Condomless Sex: Disentangling Personal Values From Public Health Priorities. Am J Public Health 107:1572-1576
Janjua, Sumbal A; Staziaki, Pedro V; Szilveszter, Balint et al. (2017) Presence, Characteristics, and Prognostic Associations of Carotid Plaque Among People Living With HIV. Circ Cardiovasc Imaging 10:
Manickam, Cordelia; Martinot, Amanda J; Jones, Rhianna A et al. (2017) Hepatic immunopathology during occult hepacivirus re-infection. Virology 512:48-55
Levison, Julie H; Bogart, Laura M; Khan, Iman F et al. (2017) ""Where It Falls Apart"": Barriers to Retention in HIV Care in Latino Immigrants and Migrants. AIDS Patient Care STDS 31:394-405
Mayer, Kenneth H; Jones, Daniel; Oldenburg, Catherine et al. (2017) Optimal HIV Postexposure Prophylaxis Regimen Completion With Single Tablet Daily Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine Compared With More Frequent Dosing Regimens. J Acquir Immune Defic Syndr 75:535-539

Showing the most recent 10 out of 944 publications