This application proposes continued funding of the Harvard University Center for AIDS Research (HU CFAR). HU CFAR is the umbrella organization for AIDS research at Harvard, operating out of the Provost's Office. It represents each of the Harvard affiliated schools as well as the affiliated hospitals, including Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Massachusetts General Hospital, Brigham & Women's Hospital. In addition, it includes the Lemuel Shattuck Hospital and Fenway Health, extending its reach to additional clinical populations and translational research sites outside Harvard. HU CFAR builds collaborations and provides infrastructure support to coordinate and promote emerging opportunities in basic, clinical, behavioral, and translational HIV research. Research emphasis among investigators includes studies of molecular virology, pathogenesis, host immune responses, epidemiology, treatment, vaccines and prevention. CFAR also oversees 3 Scientific Programs (Epidemiology and Implementation Science, International, and HIV Vaccines) as well as 3 Scientific Working Groups (HIV Eradication, TB-HIV Co-infection and Health Equity). Six Core facilities have also been identified for HU CFAR support: Clinical, Biostatistics and Bioinformatics, Humanized Mouse, Advanced Technologies, Behavioral and Social Sciences and Biosafety Level 3. In addition, an Administrative Core will provide strategic planning and fiscal oversight, and a Developmental Core will support innovative pilot projects related to the goals of the scientific programs and scientific working groups. Undertaking the following specific aims, the HU CFAR will continue to expand, promote, and facilitate collaborative, multidisciplinary activities in AID research among CFAR members as the Harvard University model for collaborative inter-institutional interactions:
Aim 1 : to facilitate and expand synergistic multidisciplinary collaborations among the diverse and highly successful HU-affiliated HIV/AIDS researchers and their trainees, Aim 2; to promote new interactions and support innovative research initiatives capable of more effectively addressing key HIV/AIDS related research questions aimed at bringing an end to the epidemic, Aim 3: to attract, engage, support and mentor the next generation of early career scientists into HIV/AIDS research.
The HU CFAR is a comprehensive Center providing the infrastructure to integrate Harvard University's multidisciplinary AIDS-related clinical and basic research programs. This provides a unique platform to maximize the contribution to public health by Harvard's HIV/AIDS investigators.
|Kirtane, Ameya R; Abouzid, Omar; Minahan, Daniel et al. (2018) Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy. Nat Commun 9:2|
|Mayer, Kenneth H; Chan, Philip A; R Patel, Rupa et al. (2018) Evolving Models and Ongoing Challenges for HIV Preexposure Prophylaxis Implementation in the United States. J Acquir Immune Defic Syndr 77:119-127|
|Calabrese, Sarah K; Earnshaw, Valerie A; Krakower, Douglas S et al. (2018) A Closer Look at Racism and Heterosexism in Medical Students' Clinical Decision-Making Related to HIV Pre-Exposure Prophylaxis (PrEP): Implications for PrEP Education. AIDS Behav 22:1122-1138|
|Richterman, Aaron; Cheung, Hoi Ching; Meiselbach, Mark K et al. (2018) Risk Factors for Self-Reported Cholera Within HIV-Affected Households in Rural Haiti. Open Forum Infect Dis 5:ofy127|
|Lodi, Sara; Günthard, Huldrych F; Dunn, David et al. (2018) Effect of immediate initiation of antiretroviral treatment on the risk of acquired HIV drug resistance. AIDS 32:327-335|
|Luong Nguyen, Liem B; Yazdanpanah, Yazdan; Maman, David et al. (2018) Voluntary Community Human Immunodeficiency Virus Testing, Linkage, and Retention in Care Interventions in Kenya: Modeling the Clinical Impact and Cost-effectiveness. Clin Infect Dis 67:719-726|
|Gholizadeh, Shadi; Rooney, Benjamin M; Merz, Erin L et al. (2018) Body Image and Condomless Anal Sex Among Sexual Minority Men Living with HIV. AIDS Behav 22:658-662|
|Howe, Chanelle J; Dulin-Keita, Akilah; Cole, Stephen R et al. (2018) Evaluating the Population Impact on Racial/Ethnic Disparities in HIV in Adulthood of Intervening on Specific Targets: A Conceptual and Methodological Framework. Am J Epidemiol 187:316-325|
|Andersen, Lena S; Magidson, Jessica F; O'Cleirigh, Conall et al. (2018) A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa. J Health Psychol 23:776-787|
|North, Crystal M; Allen, Joseph G; Okello, Samson et al. (2018) HIV Infection, Pulmonary Tuberculosis, and COPD in Rural Uganda: A Cross-Sectional Study. Lung 196:49-57|
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