1. Core Mission The goal of the Developmental Core is to stimulate new investigator-initiated research breakthroughs in HIV/AIDS through the support of CFAR faculty utilizing three major mechanisms;direct financial support to allow recruitment of talented faculty in targeted areas who complement and enhance the CFAR HIV research agenda (Faculty Development);research support through the peer-reviewed Small Grants and Emerging Opportunities Awards;and the fostering of young investigators through a structured training and mentoring program, the Mentored Clinical Research Scientist Program (MCRSP). The MCRSP was initiated in the current cycle of funding, and it will be continued and expanded in the next funding cycle to reach a larger pool of junior trainees engaged in HIV-related research. Ultimately a more formal program in mentoring across the Cores will be developed. Much has been accomplished over the past four years due to the impact of the CFAR Developmental Core in support of HIV/AIDS research. The effectiveness of the Developmental Core is due, in part, to the fact that nearly all HIV-related research at Duke is coordinated and led by the Duke CFAR faculty, resulting in a cohesive research community that is accustomed to working together across academic departmental boundaries to form multidisciplinary and interdepartmental teams. Illustrative of this collaborative environment are the numerous publications co-authored by members of different departments (See Table I and References 1-28 for a listing of key CFAR personnel who are either first or senior authors, and their collaborators, on publications since 2004). The Developmental Core's role in this process has been in the implementation and coordination of the supportive mechanisms defined above. Final decisions concerning the establishment of priorities and allocation of resources resides with the CFAR Executive Committee and CFAR leadership, which allows flexibility in resource allocation to take advantage of opportunities and to correct weaknesses if any. Institutional support in the form of matching funds from the Dean of the School of Medicine has been made available to further enhance CFAR Developmental Core activities, providing additional leveraged resources to expand Faculty Development, and Small Grants and Emerging Opportunities Awards. Thus, as the Duke CFAR moves forward in its second funding cycle, there is a firm foundation of coordination, cooperation and communication among CFAR members, members of the Duke research community at-large who are working on HIV-related projects, and the leadership ofthe School of Medicine.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Zhang, Helen L; Rhea, Sarah K; Hurt, Christopher B et al. (2018) HIV Preexposure Prophylaxis Implementation at Local Health Departments: A Statewide Assessment of Activities and Barriers. J Acquir Immune Defic Syndr 77:72-77
Cichowitz, Cody; Mazuguni, Festo; Minja, Linda et al. (2018) Vulnerable at Each Step in the PMTCT Care Cascade: High Loss to Follow Up During Pregnancy and the Postpartum Period in Tanzania. AIDS Behav :
Tabb, Zachary J; Mmbaga, Blandina T; Gandhi, Monica et al. (2018) Antiretroviral drug concentrations in hair are associated with virologic outcomes among young people living with HIV in Tanzania. AIDS 32:1115-1123
Williams, Wilton B; Han, Qifeng; Haynes, Barton F (2018) Cross-reactivity of HIV vaccine responses and the microbiome. Curr Opin HIV AIDS 13:9-14
Cherenack, Emily M; Sikkema, Kathleen J; Watt, Melissa H et al. (2018) Avoidant Coping Mediates the Relationship Between Self-Efficacy for HIV Disclosure and Depression Symptoms Among Men Who Have Sex with Men Newly Diagnosed with HIV. AIDS Behav 22:3130-3140
Sikkema, Kathleen J; Mulawa, Marta I; Robertson, Corne et al. (2018) Improving AIDS Care After Trauma (ImpACT): Pilot Outcomes of a Coping intervention Among HIV-Infected Women with Sexual Trauma in South Africa. AIDS Behav 22:1039-1052
Blasi, Maria; Negri, Donatella; LaBranche, Celia et al. (2018) IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells. Commun Biol 1:134
Collins, Lauren F; Chan, Austin; Zheng, Jiayin et al. (2018) Direct-Acting Antivirals Improve Access to Care and Cure for Patients With HIV and Chronic HCV Infection. Open Forum Infect Dis 5:ofx264
Wills, Saintedym; Hwang, Kwan-Ki; Liu, Pinghuang et al. (2018) HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis. J Virol 92:
Watt, Melissa H; Knippler, Elizabeth T; Knettel, Brandon A et al. (2018) HIV Disclosure Among Pregnant Women Initiating ART in Cape Town, South Africa: Qualitative Perspectives During the Pregnancy and Postpartum Periods. AIDS Behav 22:3945-3956

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