CoreD Core D Molecular Virology Core is comprised of an HIV/AIDS DNA sequence analysis component, a BSL-3 virology facility, and microRNA function/RNA interference technologies to serve the evolving needs of basic and clinical translational HIV and associated opportunistic infections research at Duke University.
The specific aims of the Molecular Virology Core are: 1. Provision of Core Services to facilitate the implementation of DNA sequencing, molecular virology assays, and state-of-the-art support for RNA interference and microRNA functional analyses in CFAR laboratories through shared resources in a cost efficient manner. 2. To provide expertise and core resources related to the role of specific human genes in the replication and pathogenesis of HIV-1, opportunistic infections or AIDS-associated malignancies. 3. To stimulate interdisciplinary collaborations between academia and industry to further improve the technology offered by the Core and to provide a solid resource on which collaborations can be fostered. 4. To provide education and training opportunities to CFAR scientists in existing and newly developed virologic methodologies. In order to achieve these aims, the Molecular Virology Core is A) committed to maintaining a high quality of reagents and data through multiple QA/QC procedures and B) establishing a virologic resource that is based on current and future scientific needs of CFAR investigators.

Public Health Relevance

By providing state-of-the-art technical and scientific support for HIV-1 research at Duke and in the wider Research Triangle community, the Molecular Virology Core provides important, and often essential, support for research into novel anti-HIV drugs and into potential HIV vaccine approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI064518-09
Application #
8500112
Study Section
Special Emphasis Panel (ZAI1-JBS-A)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
9
Fiscal Year
2013
Total Cost
$79,300
Indirect Cost
$79,300
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Mkhize, Nonhlanhla N; Durgiah, Raveshni; Ashley, Vicki et al. (2016) Broadly neutralizing antibody specificities detected in the genital tract of HIV-1 infected women. AIDS 30:1005-14
Brochhausen, Mathias; Zheng, Jie; Birtwell, David et al. (2016) OBIB-a novel ontology for biobanking. J Biomed Semantics 7:23
Kidd, Marie J; Jackson, Katherine J L; Boyd, Scott D et al. (2016) DJ Pairing during VDJ Recombination Shows Positional Biases That Vary among Individuals with Differing IGHD Locus Immunogenotypes. J Immunol 196:1158-64
Ramaiya, Megan K; Sullivan, Kristen A; O' Donnell, Karen et al. (2016) A Qualitative Exploration of the Mental Health and Psychosocial Contexts of HIV-Positive Adolescents in Tanzania. PLoS One 11:e0165936
Kelly, Matthew S; Crotty, Eric J; Rattan, Mantosh S et al. (2016) Chest Radiographic Findings and Outcomes of Pneumonia Among Children in Botswana. Pediatr Infect Dis J 35:257-62
Healy, Zachary R; Murdoch, David M (2016) OMIP-036: Co-inhibitory receptor (immune checkpoint) expression analysis in human T cell subsets. Cytometry A 89:889-892
Park, Se Eun; Pak, Gi Deok; Aaby, Peter et al. (2016) The Relationship Between Invasive Nontyphoidal Salmonella Disease, Other Bacterial Bloodstream Infections, and Malaria in Sub-Saharan Africa. Clin Infect Dis 62 Suppl 1:S23-31
Pacek, Lauren R; Sweitzer, Maggie M; McClernon, F Joseph (2016) Non-cigarette tobacco and poly-tobacco use among persons living with HIV drawn from a nationally representative sample. Drug Alcohol Depend 162:251-5
Bengtson, Angela M; Pence, Brian W; Gaynes, Bradley N et al. (2016) Improving Depression Among HIV-Infected Adults: Transporting the Effect of a Depression Treatment Intervention to Routine Care. J Acquir Immune Defic Syndr 73:482-488
Abedini-Nassab, Roozbeh; Joh, Daniel Y; Albarghouthi, Faris et al. (2016) Magnetophoretic transistors in a tri-axial magnetic field. Lab Chip 16:4181-4188

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