CoreD Core D Molecular Virology Core is comprised of an HIV/AIDS DNA sequence analysis component, a BSL-3 virology facility, and microRNA function/RNA interference technologies to serve the evolving needs of basic and clinical translational HIV and associated opportunistic infections research at Duke University.
The specific aims of the Molecular Virology Core are: 1. Provision of Core Services to facilitate the implementation of DNA sequencing, molecular virology assays, and state-of-the-art support for RNA interference and microRNA functional analyses in CFAR laboratories through shared resources in a cost efficient manner. 2. To provide expertise and core resources related to the role of specific human genes in the replication and pathogenesis of HIV-1, opportunistic infections or AIDS-associated malignancies. 3. To stimulate interdisciplinary collaborations between academia and industry to further improve the technology offered by the Core and to provide a solid resource on which collaborations can be fostered. 4. To provide education and training opportunities to CFAR scientists in existing and newly developed virologic methodologies. In order to achieve these aims, the Molecular Virology Core is A) committed to maintaining a high quality of reagents and data through multiple QA/QC procedures and B) establishing a virologic resource that is based on current and future scientific needs of CFAR investigators.

Public Health Relevance

By providing state-of-the-art technical and scientific support for HIV-1 research at Duke and in the wider Research Triangle community, the Molecular Virology Core provides important, and often essential, support for research into novel anti-HIV drugs and into potential HIV vaccine approaches.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Special Emphasis Panel (ZAI1-JBS-A)
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Duke University
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Abler, Laurie; Sikkema, Kathleen J; Watt, Melissa H et al. (2015) Traumatic stress and the mediating role of alcohol use on HIV-related sexual risk behavior: results from a longitudinal cohort of South African women who attend alcohol-serving venues. J Acquir Immune Defic Syndr 68:322-8
Watt, Melissa H; Sikkema, Kathleen J; Abler, Laurie et al. (2015) Experiences of forced sex among female patrons of alcohol-serving venues in a South African township. J Interpers Violence 30:1533-52
Payne, Tamika L; Blackinton, Jeff; Frisbee, Alyse et al. (2014) Transcriptional and posttranscriptional regulation of cytokine gene expression in HIV-1 antigen-specific CD8+ T cells that mediate virus inhibition. J Virol 88:9514-28
Perez, Lautaro G; Chen, Haiyan; Liao, Hua-Xin et al. (2014) Envelope glycoprotein binding to the integrin ?4?7 is not a general property of most HIV-1 strains. J Virol 88:10767-77
Gao, Feng; Bonsignori, Mattia; Liao, Hua-Xin et al. (2014) Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. Cell 158:481-91
Zolla-Pazner, Susan; deCamp, Allan; Gilbert, Peter B et al. (2014) Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection. PLoS One 9:e87572
Richards, Adam J; Staats, Janet; Enzor, Jennifer et al. (2014) Setting objective thresholds for rare event detection in flow cytometry. J Immunol Methods 409:54-61
Pollara, Justin; Bonsignori, Mattia; Moody, M Anthony et al. (2014) HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities. J Virol 88:7715-26
Voronin, Yegor; Mofenson, Lynne M; Cunningham, Coleen K et al. (2014) HIV monoclonal antibodies: a new opportunity to further reduce mother-to-child HIV transmission. PLoS Med 11:e1001616
Watt, Melissa H; Eaton, Lisa A; Choi, Karmel W et al. (2014) "It's better for me to drink, at least the stress is going away": perspectives on alcohol use during pregnancy among South African women attending drinking establishments. Soc Sci Med 116:119-25

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