The mission of the Biostatistics and Computational Biology Core (BCB) is to provide quantitative suppor for intramural collaboration and coordination of all AIDS-related research activities at Duke, thereby increasing the scientific impact of research done by CFAR investigators. We will work closely with the other CFAR Core leadership to anticipate the needs of HIV-related scholarship at Duke and create the appropriate statistical methods and computer infrastructure to fulfill these needs. Key areas that we anticipate will be critical needs for the Duke CFAR are: 1. Biostatistical consulting for social and behavioral sciences research and clinical trials 2. Laboratory assay development and analysis for flow cytometry and molecular virology 3. Mentoring and education in statistics and quantitative analysis 4. Data management and integration of laboratory and clinical data CFAR investigators can use the Core to consult about statistical or computational biology issues, collaborate on a manuscript or grant, upgrade their quantitative skills by taking a statistics or computational module, or simply make use of software tools developed by Core members. To facilitate such Core-Core interactions, we adopt a model where a single member is the primary contact for each CFAR Core, allowing us to specialize according to our skill sets and scientific interests while also becoming deeply familiar with the relevant science. During the first CFAR funding cycle, the BCB Core has been extensively utilized and has provided critical support to investigators from the Flow Cytometry, Molecular Virology, Social and Behavioral Sciences and Clinical Cores. In addition, BCB Core investigators have made independent scientific contributions through the development of innovative software for multi-parameter flow cytometry, and developed methods for inferring the natural histories of HIV sequences, inferring the V(D)J recombination components for immunoglobulin and T-cell receptor DNA sequences, predicting Hl_A binding by potential peptide T-cell epitopes, and enhanced data processing for cellular tracking, and ELISA, Luminex and gene expression microarray results.

Public Health Relevance

Duke University does not have any other Biostatistical consulting service that is focused on HIV research and in the absence of the BCB Core, investigators would have to find an independent biostatistician to consult on methodological issues with experimental design and data analysis. The BCB Core thus provides a unique and valuable statistical consulting resource to the Duke HIV research community.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30AI064518-10
Application #
8712321
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
City
Durham
State
NC
Country
United States
Zip Code
27705
Mkhize, Nonhlanhla N; Durgiah, Raveshni; Ashley, Vicki et al. (2016) Broadly neutralizing antibody specificities detected in the genital tract of HIV-1 infected women. AIDS 30:1005-14
Brochhausen, Mathias; Zheng, Jie; Birtwell, David et al. (2016) OBIB-a novel ontology for biobanking. J Biomed Semantics 7:23
Kidd, Marie J; Jackson, Katherine J L; Boyd, Scott D et al. (2016) DJ Pairing during VDJ Recombination Shows Positional Biases That Vary among Individuals with Differing IGHD Locus Immunogenotypes. J Immunol 196:1158-64
Ramaiya, Megan K; Sullivan, Kristen A; O' Donnell, Karen et al. (2016) A Qualitative Exploration of the Mental Health and Psychosocial Contexts of HIV-Positive Adolescents in Tanzania. PLoS One 11:e0165936
Kelly, Matthew S; Crotty, Eric J; Rattan, Mantosh S et al. (2016) Chest Radiographic Findings and Outcomes of Pneumonia Among Children in Botswana. Pediatr Infect Dis J 35:257-62
Healy, Zachary R; Murdoch, David M (2016) OMIP-036: Co-inhibitory receptor (immune checkpoint) expression analysis in human T cell subsets. Cytometry A 89:889-892
Park, Se Eun; Pak, Gi Deok; Aaby, Peter et al. (2016) The Relationship Between Invasive Nontyphoidal Salmonella Disease, Other Bacterial Bloodstream Infections, and Malaria in Sub-Saharan Africa. Clin Infect Dis 62 Suppl 1:S23-31
Pacek, Lauren R; Sweitzer, Maggie M; McClernon, F Joseph (2016) Non-cigarette tobacco and poly-tobacco use among persons living with HIV drawn from a nationally representative sample. Drug Alcohol Depend 162:251-5
Bengtson, Angela M; Pence, Brian W; Gaynes, Bradley N et al. (2016) Improving Depression Among HIV-Infected Adults: Transporting the Effect of a Depression Treatment Intervention to Routine Care. J Acquir Immune Defic Syndr 73:482-488
Abedini-Nassab, Roozbeh; Joh, Daniel Y; Albarghouthi, Faris et al. (2016) Magnetophoretic transistors in a tri-axial magnetic field. Lab Chip 16:4181-4188

Showing the most recent 10 out of 390 publications