The mission of the University of Rochester (UR) Center for AIDS Research (CFAR) is to support a multidisciplinary environment that promotes and enhances HIV/AIDS research at UR, with the goal of improving the prevention, detection and treatment of HIV infection, AIDS and related disease processes. The UR CFAR will achieve this mission by providing the leadership, services and infrastructure necessary to: establish multidisciplinary collaborations that achieve high-impact discoveries; support the early career development of diverse young HIV/AIDS investigators; and to establish a distinctive scientific identity for the Rochester CFAR, placing it at the forefront of HIV/AIDS research. During our funding cycle as a Developmental CFAR (D-CFAR), we have successfully recruited many new investigators into HIV/AIDS research at the UR. As a result, almost two-thirds (63%) of our membership are NIH-defined early stage or new investigators, or investigators new to HIV/AIDS (in roughly equal proportions). We have also developed innovative approaches to program and collaboration building, with the result that the number of HIV/AIDS investigators at UR with R01 or equivalent support has risen by 53% since inception of our D-CFAR, while collaborative research activity (publications and funded grants) have risen by 40% and 56%, respectively. Building on this success, we propose five Aims.
Aim 1 will provide leadership that creates an outstanding scientific environment, and that strategically positions UR at the forefront of HIV/AIDS research.
Aim 2 will stimulate new, innovative research and multidisciplinary collaborations that result in high impact discoveries. It will also establish a unique scientific identity for the UR CFAR in Optics & Imaging Sciences and in RNA Biology.
Aim 3 will identify and mentor the next generation of HIV/AIDS investigators, and Aim 4 will provide an integrated set of scientific Cores that enable cutting-edge HIV research, and that proactively meet investigator needs. Finally, Aim 5 will stimulate communication and engagement with the full range of communities that the UR CFAR serves.

Public Health Relevance

The mission of the University of Rochester (UR) Center for AIDS Research (CFAR) is to support a multidisciplinary environment that promotes and enhances HIV/AIDS research at UR, with the goal of improving the prevention, detection and treatment of HIV infection, AIDS and related disease processes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI078498-08
Application #
8830904
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Beaubien, Candice M
Project Start
2008-05-01
Project End
2016-04-30
Budget Start
2015-05-01
Budget End
2016-04-30
Support Year
8
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Rochester
Department
Microbiology/Immun/Virology
Type
School of Medicine & Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Rice, John D; Strawderman, Robert L; Johnson, Brent A (2018) Regularity of a renewal process estimated from binary data. Biometrics 74:566-574
Nogales, Aitor; Piepenbrink, Michael S; Wang, Jiong et al. (2018) A Highly Potent and Broadly Neutralizing H1 Influenza-Specific Human Monoclonal Antibody. Sci Rep 8:4374
Zhou, Tian; Su, Hang; Dash, Prasanta et al. (2018) Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials 151:53-65
Horita, Yasuhiro; Alsultan, Abdullah; Kwara, Awewura et al. (2018) Evaluation of the Adequacy of WHO Revised Dosages of the First-Line Antituberculosis Drugs in Children with Tuberculosis Using Population Pharmacokinetic Modeling and Simulations. Antimicrob Agents Chemother 62:
Yang, Hongmei; Holden-Wiltse, Jeanne; Topham, David J et al. (2018) Maximum Likelihood Estimation of Titer via a Power Family of Four-Parameter Logistic Model. J Biopharm Stat 28:492-500
Belashov, Ivan A; Crawford, David W; Cavender, Chapin E et al. (2018) Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription. Nucleic Acids Res 46:6401-6415
McMillan, JoEllyn; Szlachetka, Adam; Zhou, Tian et al. (2018) Pharmacokinetic testing of a first generation cabotegravir prodrug in rhesus macaques. AIDS :
Hammond, Jennetta W; Qiu, Wen Q; Marker, Daniel F et al. (2018) HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q. Glia 66:2563-2574
Dompreh, Albert; Tang, Xiaoli; Zhou, Jianlin et al. (2018) Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis. Antimicrob Agents Chemother 62:
Leblanc, Natalie M; Mitchell, Jason (2018) Providers' Perceptions of Couples' HIV Testing and Counseling (CHTC): Perspectives From a U.S. HIV Epicenter. Couple Family Psychol 7:22-33

Showing the most recent 10 out of 192 publications