Chicago has the 6th highest HIV prevalence of large cities in the US;three medical institutions are located right in the middle of the communities with the highest prevalence of HIV in Chicago. More than 100 investigators in these institutions are currently involved in HIV/AIDS research. This proposal is to establish a Chicago Developmental Center for AIDS Research (D-CFAR) that will include Rush University Medical Center (RUMC), the University of Illinois at Chicago (UIC), and the Cook County Bureau of Health Services (Cook County) and will foster HIV/AIDS related research productivity. Dr. Alan Landay (RUMC) will be the Director and Dr. Robert Bailey (UIC) will be the Co-Director. The D-CFAR will build upon existing collaborative research efforts in basic, clinical, and behavioral science and will work toward expanding research opportunities for junior HIV investigators and to engage senior investigators from other disciplines in HIV/AIDS research. We plan to 1) develop an infrastructure that enhances HIV research across institutional boundaries, 2) work toward establishing interdisciplinary collaborations between investigators in the basic, social and behavioral and clinical areas of research, 3) encourage innovative research in HIV/AIDS, 4) improve communication between Chicago D-CFAR participants by creating a web site (www.ChicagoDCFAR. org), distributing a database of participants and emailing news of D-CFAR events to all participants, 5) develop access to HIV educational material, 6) develop a communication strategy for bringing advances in HIV/AIDS research to the community and 7) build an infrastructure to enable us to move from a D-CFAR to a CFAR. We will accomplish these goals by creating Cores and Emphasis Areas. There will be: an Administrative Core (Drs. Alan Landay and Linda Baum);a Developmental Core (Drs. Greg Spear and Ron Hershow);a Basic Science Core (Drs. Michael Caffrey and James Bremer);a Clinical Core (Drs. Audrey French and Richard Novak);and a Social and Behavioral Sciences Core (Drs. Judith Levy and Robert Bailey). We will actively promote research in: HIV and Women (Ms. Kathleen Weber);HIV and Aging (Dr. Pauline Maki) and Drug Abuse and HIV (Dr. Celeste Napier).

Public Health Relevance

The Formation of a Chicago D-CFAR will enable us to create an environment that fosters collaboration between investigators at RUMC, UIC and Cook County and will promote translational research and lead to a better understanding of HIV pathogenesis and better ways to prevent, detect and treat HIV/AIDS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI082151-04
Application #
8320290
Study Section
Special Emphasis Panel (ZAI1-SV-A (J3))
Program Officer
Beaubien, Candice M
Project Start
2009-08-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
4
Fiscal Year
2012
Total Cost
$732,407
Indirect Cost
$124,596
Name
Rush University Medical Center
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
068610245
City
Chicago
State
IL
Country
United States
Zip Code
60612
Hotton, Anna L; Boodram, Basmattee (2016) Gender, Transience, Network Partnerships and Risky Sexual Practices Among Young Persons who Inject Drugs. AIDS Behav :
Culbert, Gabriel J; Bazazi, Alexander R; Waluyo, Agung et al. (2016) The Influence of Medication Attitudes on Utilization of Antiretroviral Therapy (ART) in Indonesian Prisons. AIDS Behav 20:1026-38
Rubin, Leah H; Pyra, Maria; Cook, Judith A et al. (2016) Post-traumatic stress is associated with verbal learning, memory, and psychomotor speed in HIV-infected and HIV-uninfected women. J Neurovirol 22:159-69
Lurain, Nell S; Hanson, Barbara A; Hotton, Anna L et al. (2016) The Association of Human Cytomegalovirus with Biomarkers of Inflammation and Immune Activation in HIV-1-Infected Women. AIDS Res Hum Retroviruses 32:134-43
Rubin, Leah H; Wu, Minjie; Sundermann, Erin E et al. (2016) Elevated stress is associated with prefrontal cortex dysfunction during a verbal memory task in women with HIV. J Neurovirol 22:840-851
Senkomago, Virginia; Backes, Danielle M; Hudgens, Michael G et al. (2016) Higher HPV16 and HPV18 Penile Viral Loads Are Associated With Decreased Human Papillomavirus Clearance in Uncircumcised Kenyan Men. Sex Transm Dis 43:572-8
Popovich, Kyle J; Zawitz, Chad; Weinstein, Robert A et al. (2015) The Intersecting Epidemics of Human Immunodeficiency Virus, Community-Associated Methicillin-Resistant Staphylococcus aureus, and Incarceration. Open Forum Infect Dis 2:ofv148
Mata, Mariana M; Napier, T Celeste; Graves, Steven M et al. (2015) Methamphetamine decreases CD4 T cell frequency and alters pro-inflammatory cytokine production in a model of drug abuse. Eur J Pharmacol 752:26-33
Voigt, Robin M; Keshavarzian, Ali; Losurdo, John et al. (2015) HIV-associated mucosal gene expression: region-specific alterations. AIDS 29:537-46
Boodram, Basmattee; Mackesy-Amiti, Mary-Ellen; Latkin, Carl (2015) The role of social networks and geography on risky injection behaviors of young persons who inject drugs. Drug Alcohol Depend 154:229-35

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