Overall goals ofthe Basic Science Core includes: contributions to the National CFAR Mission, stimulating scientific collaboration in interdisciplinary and translational research, providing scientific leadership and institutional infrastructure dedicated to AIDS research, fostering scientific communication, sponsoring training and education, promoting knowledge of CFAR research findings and the importance of AIDS research through community outreach, promoting and supporting innovative NIH HIV/AIDS research initiatives, establishing collaborative research between CFARs, and supporting HIV/AIDS research networks, facilitating technology transfer and development through promotion of scientific interactions between CFARs and industry, and supporting research on prevention and treatment of HIV infection in hard-to-reach populations, especially in inner city, rural poor, and disadvantaged minorities. The mission ofthe Basic Science Core is to develop, refine, and provide training and services to HIV/AIDS investigators in DC for the assays used to evaluate and quantify HIV replication and gene expression, characterize HIV disease using immunologic, genomics and proteomics approaches, and facilitate drug development by providing small animal models of HIV disease. The assays, reagents, and training offered by this Core are designed to support basic, clinical, and translational research in the prevention, detection, and treatment of HIV infection and AIDS.
The aims i nclude: to provide technical support and laboratory services to promote HIV-related basic science research and translational studies through access to the following services and to provide mentorship and training opportunities for junior, minority and new HIV/AIDS investigators.
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|Xia, Jie; Hu, Huabin; Xue, Wenjie et al. (2018) The discovery of novel HDAC3 inhibitors via virtual screening and in vitro bioassay. J Enzyme Inhib Med Chem 33:525-535|
|Pérez-Losada, Marcos; Arenas, Miguel; Castro-Nallar, Eduardo (2018) Microbial sequence typing in the genomic era. Infect Genet Evol 63:346-359|
|Leal, Fabio E; Menezes, Soraya Maria; Costa, Emanuela A S et al. (2018) Comprehensive Antiretroviral Restriction Factor Profiling Reveals the Evolutionary Imprint of the ex Vivo and in Vivo IFN-? Response in HTLV-1-Associated Neuroinflammation. Front Microbiol 9:985|
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|Xia, Jie; Feng, Bo; Shao, Qianhang et al. (2017) Virtual Screening against Phosphoglycerate Kinase 1 in Quest of Novel Apoptosis Inhibitors. Molecules 22:|
|Levy, Matthew E; Phillips 2nd, Gregory; Magnus, Manya et al. (2017) A Longitudinal Analysis of Treatment Optimism and HIV Acquisition and Transmission Risk Behaviors Among Black Men Who Have Sex with Men in HPTN 061. AIDS Behav 21:2958-2972|
|Pollack, Ross A; Jones, R Brad; Pertea, Mihaela et al. (2017) Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape. Cell Host Microbe 21:494-506.e4|
|Avdoshina, Valeria; Caragher, Seamus P; Wenzel, Erin D et al. (2017) The viral protein gp120 decreases the acetylation of neuronal tubulin: potential mechanism of neurotoxicity. J Neurochem 141:606-613|
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