Overall goals ofthe Basic Science Core includes: contributions to the National CFAR Mission, stimulating scientific collaboration in interdisciplinary and translational research, providing scientific leadership and institutional infrastructure dedicated to AIDS research, fostering scientific communication, sponsoring training and education, promoting knowledge of CFAR research findings and the importance of AIDS research through community outreach, promoting and supporting innovative NIH HIV/AIDS research initiatives, establishing collaborative research between CFARs, and supporting HIV/AIDS research networks, facilitating technology transfer and development through promotion of scientific interactions between CFARs and industry, and supporting research on prevention and treatment of HIV infection in hard-to-reach populations, especially in inner city, rural poor, and disadvantaged minorities. The mission ofthe Basic Science Core is to develop, refine, and provide training and services to HIV/AIDS investigators in DC for the assays used to evaluate and quantify HIV replication and gene expression, characterize HIV disease using immunologic, genomics and proteomics approaches, and facilitate drug development by providing small animal models of HIV disease. The assays, reagents, and training offered by this Core are designed to support basic, clinical, and translational research in the prevention, detection, and treatment of HIV infection and AIDS.
The aims i nclude: to provide technical support and laboratory services to promote HIV-related basic science research and translational studies through access to the following services and to provide mentorship and training opportunities for junior, minority and new HIV/AIDS investigators.
|Lam, Sharon; Sung, Julia; Cruz, Conrad et al. (2015) Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy. Mol Ther 23:387-95|
|Peterson, James; Cota, Michelle; Gray, Holly et al. (2015) Technology use in linking criminal justice reentrants to HIV care in the community: a qualitative formative research study. J Health Commun 20:245-51|
|Bukrinsky, Michael (2015) Extracellular cyclophilins in health and disease. Biochim Biophys Acta 1850:2087-95|
|Michaud, Henri-Alexandre; SenGupta, Devi; de Mulder, Miguel et al. (2014) Cutting edge: An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells. J Immunol 193:1544-8|
|Curtis, Kimberly; Rollins, Matthew; Carryl, Heather et al. (2014) Reduction of pyramidal and immature hippocampal neurons in pediatric simian immunodeficiency virus infection. Neuroreport 25:647-52|
|Eberhart, M G; Voytek, C D; Hillier, A et al. (2014) Travel distance to HIV medical care: a geographic analysis of weighted survey data from the Medical Monitoring Project in Philadelphia, PA. AIDS Behav 18:776-82|
|Mayer, Kenneth H; Wang, Lei; Koblin, Beryl et al. (2014) Concomitant socioeconomic, behavioral, and biological factors associated with the disproportionate HIV infection burden among Black men who have sex with men in 6 U.S. cities. PLoS One 9:e87298|
|Mannheimer, Sharon B; Wang, Lei; Wilton, Leo et al. (2014) Infrequent HIV testing and late HIV diagnosis are common among a cohort of black men who have sex with men in 6 US cities. J Acquir Immune Defic Syndr 67:438-45|
|Jennelle, Lucas; Hunegnaw, Ruth; Dubrovsky, Larisa et al. (2014) HIV-1 protein Nef inhibits activity of ATP-binding cassette transporter A1 by targeting endoplasmic reticulum chaperone calnexin. J Biol Chem 289:28870-84|
|Luo, Man; Wang, Xiang Simon; Roth, Bryan L et al. (2014) Application of quantitative structure-activity relationship models of 5-HT1A receptor binding to virtual screening identifies novel and potent 5-HT1A ligands. J Chem Inf Model 54:634-47|
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