Abstract

The Tennessee Center for AIDS Research CFAR (CFAR) is located in the Southeastern US, the region with both the greatest number of new HIV-1 infections, and of persons living with HIV. Under the leadership of Dr. Simon Mallal, recruited to Vanderbilt (VU) to lead this Center, the Tennessee CFAR is a three-way partnership between a research-intensive institution (VU), a historically black medical college (Meharry Medical College, MMC), and an academically engaged state health department (Tennessee Department of Health, TDH). This CFAR's institutional and community environment is rich in opportunity, and with a culture of engagement and collaboration. The Clinical Sciences Core (CSC) will fill major gaps in the local research environment, and in so doing support the mission of the Tennessee CFAR to reduce the burden of HIV/AIDS, as well as other goals of the nationwide CFAR program. This will be accomplished through three Specific Aims: 1) To propel the use of robust observational databases for hypothesis-driven clinical and translational research across disciplines focused on reducing the overall burden of HIV/AIDS; 2) To support investigators with research projects that require access to study volunteers, and associated biological specimens; 3) To create new opportunities for clinical and translational research at MMC, as well as cross-institutional opportunities, and to facilitate MMC investigator access to such opportunities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI110527-04
Application #
9631978
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Beaubien, Candice M
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
4
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232

  Publications

Cook, Kathryn M; Gillon, Jessica; Grisso, Alison G et al. (2018) Incidence of Nephrotoxicity Among Pediatric Patients Receiving Vancomycin With Either Piperacillin-Tazobactam or Cefepime: A Cohort Study. J Pediatric Infect Dis Soc :
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Oh, Eric J; Shepherd, Bryan E; Lumley, Thomas et al. (2018) Considerations for analysis of time-to-event outcomes measured with error: Bias and correction with SIMEX. Stat Med 37:1276-1289
van der Heijden, Y F; Karim, F; Chinappa, T et al. (2018) Older age at first tuberculosis diagnosis is associated with tuberculosis recurrence in HIV-negative persons. Int J Tuberc Lung Dis 22:871-877
McDonnell, Wyatt J; Koethe, John R; Mallal, Simon A et al. (2018) High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity. Diabetes 67:2361-2376
Dash, Sabyasachi; Balasubramaniam, Muthukumar; Dash, Chandravanu et al. (2018) Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs. J Vis Exp :
Trubiano, Jason A; Grayson, M Lindsay; Thursky, Karin A et al. (2018) How antibiotic allergy labels may be harming our most vulnerable patients. Med J Aust 208:469-470
Norton, Allison Eaddy; Konvinse, Katherine; Phillips, Elizabeth J et al. (2018) Antibiotic Allergy in Pediatrics. Pediatrics 141:
Phillips, Elizabeth J (2018) NEW STRATEGIES TO PREDICT AND PREVENT SERIOUS IMMUNOLOGICALLY MEDIATED ADVERSE DRUG REACTIONS. Trans Am Clin Climatol Assoc 129:74-87
Rebeiro, Peter F; McPherson, Tristan D; Goggins, Kathryn M et al. (2018) Health Literacy and Demographic Disparities in HIV Care Continuum Outcomes. AIDS Behav 22:2604-2614

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