Abstract

Epidemiological data strongly suggest the involvement of an infectious agent distinct from HIV in the causation of K.S. The frequent occurrence of endemic and epidemic K.S. in both adults and children in Uganda and the collaboration between the Division of Infectious Diseases at CWRU and the Uganda Cancer Institute afford a unique opportunity to study the etiology of K.S. in depth. From a collaboration between this laboratory and the laboratory of Dr. Edward Mbidde of the Uganda Cancer Institute, we will obtain various endemic and epidemic K.S. tumor samples and patient sera for comparative studies. The K.S. patient tissues and sera will be used to test the hypothesis that a highly cell associated virus may be responsible for the various forms K.S. Specifically, we seek to Specific Aim 1: Establish in vitro culture of lymphocytes and tumor cells from epidemic and endemic K.S. patients.
Specific Aim 2 : Characterize the epidemic and endemic K.S. tumor cells in culture.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR039750-09
Application #
6235747
Study Section
Project Start
1997-03-01
Project End
1998-02-28
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
9
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Das, Lopa M; Binko, Amy M; Traylor, Zachary P et al. (2018) Defining the timing of 25(OH)D rescue following nitrogen mustard exposure. Cutan Ocul Toxicol 37:127-132
Griffith, Alexis D; Zaidi, Asifa K; Pietro, Ashley et al. (2018) A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice. Sci Rep 8:14451
Zaidi, Asifa K; Spaunhurst, Katrina; Sprockett, Daniel et al. (2018) Characterization of the facial microbiome in twins discordant for rosacea. Exp Dermatol 27:295-298
Bhaskaran, Natarajan; Liu, Zhihui; Saravanamuthu, Senthil S et al. (2018) Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity. Front Immunol 9:184
Mukherjee, Pranab K; Chandra, Jyotsna; Retuerto, Mauricio et al. (2018) Effect of alcohol-based hand rub on hand microbiome and hand skin health in hospitalized adult stem cell transplant patients: A pilot study. J Am Acad Dermatol 78:1218-1221.e5
Swindell, William R; Sarkar, Mrinal K; Liang, Yun et al. (2017) RNA-seq identifies a diminished differentiation gene signature in primary monolayer keratinocytes grown from lesional and uninvolved psoriatic skin. Sci Rep 7:18045
Mullin, Nathaniel K; Mallipeddi, Nikhil V; Hamburg-Shields, Emily et al. (2017) Wnt/?-catenin Signaling Pathway Regulates Specific lncRNAs That Impact Dermal Fibroblasts and Skin Fibrosis. Front Genet 8:183
Arbiser, Jack L; Nowak, Ron; Michaels, Kellie et al. (2017) Evidence for biochemical barrier restoration: Topical solenopsin analogs improve inflammation and acanthosis in the KC-Tie2 mouse model of psoriasis. Sci Rep 7:11198
Larkin, Emily; Hager, Christopher; Chandra, Jyotsna et al. (2017) The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation. Antimicrob Agents Chemother 61:
Hutnick, Melanie A; Ahsanuddin, Sayeeda; Guan, Linna et al. (2017) PEGylated Dendrimers as Drug Delivery Vehicles for the Photosensitizer Silicon Phthalocyanine Pc 4 for Candidal Infections. Biomacromolecules 18:379-385

Showing the most recent 10 out of 403 publications