Translational Research Core Facility is specifically designed to promote and facilitate involvement of human subjects for skin and skin disease-related research.
It aims to derive maximum information from human studies by providing a resource that integrates organization of patient cohorts with mechanistic studies using tissues, outcomes research, clinical trials, and laboratory investigation. This Core is structured to meet the SDRC membership's needs for human tissue, (e.g. punch biopsies, keratomes, suction blisters), to provide the SDRC membership with enabling technologies for human skin investigation (e.g. simulated solar radiation, chromometer, transepidermal water loss device), and to lead in the development of novel technologies that will benefit SDRC membership (e.g. imaging system for photodynamic therapy, skin ultrasound, in vivo confocal imaging).
It aims to provide a cost-efficient, central resource to identify and recruit volunteers to participate in human in vivo studies and/or donate blood or skin biopsy tissue for ex vivo/in vitro investigations. The utilization of core functions is expanded mainly by active interactions with physicians who refer patients and with other investigators through the Clinical and Translational Science Collaborative, Case Comprehensive Cancer Center, Center for Aids Research, and other research foci within the University. A research assistant coordinates these services. The core also aims to provide overall management of clinical trials of novel therapies brought from the laboratory to the bedside with emphasis on providing optimal translational and clinical data. A group with expertise in general trial design, regulatory and compliance aspects of human studies, assemble to efficiently direct or conduct high quality studies that arise through interaction with various investigators interested in skin research. Additionally, interactions between clinical and laboratory researchers are fostered to insert adjunctive laboratory studies to clarify mechanisms of action of therapies and pathomechanisms of disease. The core also provides support, mentoring and education regarding human research compliance, to members of the SDRC.

Public Health Relevance

TRC is a critical link for skin diseases related research, because at some point, almost every investigator needs to validate their findings in skin disease. Furthermore, the TRC is critical to the developmental therapeutics components of the SDRC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR039750-23
Application #
8526378
Study Section
Special Emphasis Panel (ZAR1-HL)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
23
Fiscal Year
2013
Total Cost
$163,594
Indirect Cost
$59,394
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Santilli, S; Kast, D R; Grozdev, I et al. (2016) Visualization of atherosclerosis as detected by coronary artery calcium and carotid intima-media thickness reveals significant atherosclerosis in a cross-sectional study of psoriasis patients in a tertiary care center. J Transl Med 14:217
Fritz, Yi; Klenotic, Philip A; Swindell, William R et al. (2016) Induction of Alternative Proinflammatory Cytokines Accounts for Sustained Psoriasiform Skin Inflammation in IL-17C+IL-6KO Mice. J Invest Dermatol :
Bhaskaran, N; Quigley, C; Weinberg, A et al. (2016) Transforming growth factor-β1 sustains the survival of Foxp3(+) regulatory cells during late phase of oropharyngeal candidiasis infection. Mucosal Immunol 9:1015-26
Hatter, Alyn D; Soler, David C; Curtis, Christine et al. (2016) Case report of individual with cutaneous immunodeficiency and novel 1p36 duplication. Appl Clin Genet 9:1-4
Hoarau, G; Mukherjee, P K; Gower-Rousseau, C et al. (2016) Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn's Disease. MBio 7:
Monin, Leticia; Gudjonsson, Johann E; Childs, Erin E et al. (2016) MCPIP1/Regnase-1 Restricts IL-17A- and IL-17C-Dependent Skin Inflammation. J Immunol :
Das, Lopa M; Binko, Amy M; Traylor, Zachary P et al. (2016) Early indicators of survival following exposure to mustard gas: Protective role of 25(OH)D. Toxicol Lett 248:9-15
Wang, Yunmei; Golden, Jackelyn B; Fritz, Yi et al. (2016) Interleukin 6 regulates psoriasiform inflammation-associated thrombosis. JCI Insight 1:e89384
Zhang, Ling-Juan; Sen, George L; Ward, Nicole L et al. (2016) Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injury. Immunity 45:119-30
Li, Yong; Stoll, Stefan W; Sekhon, Sahil et al. (2016) Transgenic expression of human amphiregulin in mouse skin: inflammatory epidermal hyperplasia and enlarged sebaceous glands. Exp Dermatol 25:187-93

Showing the most recent 10 out of 385 publications