The Skin Diseases Research Center (SDRC), based at Case Western Reserve University (Case) and University Hospitals Case Medical Center (UHCMC), brings added value to all the Northern Ohio academic medical centers by uniting basic and translational skin science. This successfully resulted in 3 federally funded Phase I SDRC-investigator initiated clinical trials. There is tremendous energy, growth, momentum, and interdisciplinary foment among the research base, comprised of 67 investigators from 24 Departments, 5 schools, and 7 institutions, with over $16M in skin disease-related research. A major goal of the SDRC is to fuel the projects of new and experienced investigators with a rich matrix of resources in order to speed the progress and enhance the quality of skin diseases research. An Administrative Core manages a Pilot &Feasibility Program (P&F), in which 9/13 of the awardees published and obtained NIH K, R, or P series awards. New institutional matching programs greatly increase the value of SDRC P&F awards. The Administrative Core also organizes Research-in Progress Luncheons, lectures and symposia to promote interaction and education, and focuses the trajectory of our basic skin research toward translation into changes in the practice of medicine. The Case SDRC coordinates user-friendly access to state-of-the-art Core services, provides expertise in skin research techniques, mentors the career development of junior members with a skin-centered emphasis in their research, assists in clinical research regulatory compliance, and promotes interfaces with advanced institutional research resources, especially Cores of the Case Clinical &Translational Sciences Center, which span proteomics, sequencing and statistics. There are 4 Scientific Cores : A) Morphology, B) Cell Culture and Molecular Technology, C) Translational Research, and D) Animal Experimentation and Wound Healing. Routine, quality controlled, high volume services complement new advanced technologies such as Spinning Disc Confocal Microscopy and a robotic 384 well format pipettor station for high throughput studies. A new dedicated server with >6 Terabytes of storage enables Electronic Lab Notebook utilization and intensive imaging and systems biology data applications.

Public Health Relevance

The SDRC gains tremendous numerical and scientific leverage at CWRU, with over $2M in University funds and $1M in UHCMC funds to be invested in the dermatology research environment and new dermatology faculty. The priming of research pathways greatly enhances the value and efficiency of each skin disease-related research grant. The focus on translation ensures maximized benefit to patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR039750-24
Application #
8733034
Study Section
Special Emphasis Panel (ZAR1-HL (M1))
Program Officer
Cibotti, Ricardo
Project Start
1997-03-01
Project End
2016-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
24
Fiscal Year
2014
Total Cost
$607,469
Indirect Cost
$220,546
Name
Case Western Reserve University
Department
Dermatology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Das, Lopa M; Binko, Amy M; Traylor, Zachary P et al. (2018) Defining the timing of 25(OH)D rescue following nitrogen mustard exposure. Cutan Ocul Toxicol 37:127-132
Griffith, Alexis D; Zaidi, Asifa K; Pietro, Ashley et al. (2018) A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice. Sci Rep 8:14451
Zaidi, Asifa K; Spaunhurst, Katrina; Sprockett, Daniel et al. (2018) Characterization of the facial microbiome in twins discordant for rosacea. Exp Dermatol 27:295-298
Bhaskaran, Natarajan; Liu, Zhihui; Saravanamuthu, Senthil S et al. (2018) Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity. Front Immunol 9:184
Mukherjee, Pranab K; Chandra, Jyotsna; Retuerto, Mauricio et al. (2018) Effect of alcohol-based hand rub on hand microbiome and hand skin health in hospitalized adult stem cell transplant patients: A pilot study. J Am Acad Dermatol 78:1218-1221.e5
Monin, Leticia; Gudjonsson, Johann E; Childs, Erin E et al. (2017) MCPIP1/Regnase-1 Restricts IL-17A- and IL-17C-Dependent Skin Inflammation. J Immunol 198:767-775
Tacastacas, Joselin D; Chan, Derek V; Carlson, Sean et al. (2017) Evaluation of O6-Benzylguanine-Potentiated Topical Carmustine for Mycosis Fungoides: A Phase 1-2 Clinical Trial. JAMA Dermatol 153:413-420
Swindell, William R; Sarkar, Mrinal K; Liang, Yun et al. (2017) RNA-seq identifies a diminished differentiation gene signature in primary monolayer keratinocytes grown from lesional and uninvolved psoriatic skin. Sci Rep 7:18045
Mullin, Nathaniel K; Mallipeddi, Nikhil V; Hamburg-Shields, Emily et al. (2017) Wnt/?-catenin Signaling Pathway Regulates Specific lncRNAs That Impact Dermal Fibroblasts and Skin Fibrosis. Front Genet 8:183
Arbiser, Jack L; Nowak, Ron; Michaels, Kellie et al. (2017) Evidence for biochemical barrier restoration: Topical solenopsin analogs improve inflammation and acanthosis in the KC-Tie2 mouse model of psoriasis. Sci Rep 7:11198

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