Over the past nine years, the Yale Core Center for Musculoskeletal Disorders (YCCMD) has become a prominent feature of the scientific landscape at Yale. Collaborations with investigators at other institutions, our invited speakers program (YCCMD Seminar Series) and our website (http://info.med.yale.edu/intmed/yccmd), have given us a national presence. Our Center is dedicated to fostering research in disorders of skeletal tissue and muscle, with the ultimate goal of improving human health. The Center is particularly interested in supporting the development and comprehensive investigation of animal models of musculoskeletal disorders. To encourage and sustain these efforts, the Center has established core laboratories with expertise in whole-animal and skeletal-tissue analyses, molecular methods and bone-cell culture. These are the Molecular Core, the Physiology Core and the Cell Core. In its nine years of funding, Center membership has increased from 25 to 47 and the funding of our research base has increased from $7,267,249 annually to $34,795,969 annually in direct dollars. During the current funding cycle there have been over a hundred original research articles and numerous chapters and reviews published that have resulted from work carried out with direct Center support. The Center has awarded 29 pilot and feasibility projects over the past 9 years. Findings from these projects have resulted in 57 original articles and reviews and have been used to support successful applications for 22 new or competing continuations of externally funded awards. In the next five years we will follow the same successful blueprint that guided us through these past four years with carefully selected new initiatives planned in response to the changing needs of Centers members. Among the planned new initiatives are to offer BAG recombineering in the Molecular Core and to offer stem cell isolation and culture in the Cell Core. The Physiology Core plans to offer microCT analysis, specialized tissue stains for bone and an extended panel of bone turnover markers. The YCCMD has been and remains committed to a vibrant interdisciplinary and challenging community of biomedical scientists at Yale.

Public Health Relevance

YCCMD supports &facilitates investigative efforts of Yale scientists in a coordinated program designed to explore animal models for musculoskeletal diseases. Our Physiology and Molecular Cores help Yale investigators analyze the musculoskeletal phenotypes of biomedically engineered and naturally occurring animal models. They provide analytical and technical support as well as training to investigators in musculoskeletal research.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1-CHW-G (M1))
Program Officer
Chen, Faye H
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Internal Medicine/Medicine
Schools of Medicine
New Haven
United States
Zip Code
McCarthy, Thomas L; Yun, Zhong; Madri, Joseph A et al. (2014) Stratified control of IGF-I expression by hypoxia and stress hormones in osteoblasts. Gene 539:141-51
Wang, Meina; VanHouten, Joshua N; Nasiri, Ali R et al. (2014) Periosteal PTHrP regulates cortical bone modeling during linear growth in mice. J Anat 225:71-82
Wang, Meina; Nasiri, Ali; VanHouten, Joshua N et al. (2014) The remarkable migration of the medial collateral ligament. J Anat 224:490-8
Scheller, Erica L; Troiano, Nancy; Vanhoutan, Joshua N et al. (2014) Use of osmium tetroxide staining with microcomputerized tomography to visualize and quantify bone marrow adipose tissue in vivo. Methods Enzymol 537:123-39
Mis, Emily K; Liem Jr, Karel F; Kong, Yong et al. (2014) Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length. Dev Biol 385:67-82
Juneja, Subhash C; Vonica, Alin; Zeiss, Caroline et al. (2014) Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia. Bone 60:148-61
Gao, Hui; Mejhert, Niklas; Fretz, Jackie A et al. (2014) Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue. Cell Metab 19:981-92
Yao, Chen; Yao, Gang-Qing; Sun, Ben-Hua et al. (2014) The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis. J Biol Chem 289:6775-90
Gattu, Arijeet K; Birkenfeld, Andreas L; Iwakiri, Yasuko et al. (2014) Pigment epithelium-derived factor (PEDF) suppresses IL-1?-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology 155:1373-85
Kacena, Melissa A; Gundberg, Caren M; Kacena 3rd, William J et al. (2013) The effects of GATA-1 and NF-E2 deficiency on bone biomechanical, biochemical, and mineral properties. J Cell Physiol 228:1594-600

Showing the most recent 10 out of 113 publications