The Genetics Core facility is one of the research cores in the Rheumatic Diseases Core Center (RDCC) at Washington University. It proposes the following Specific Aims to sustain and develop new state-of-the-art protein services to RDCC members: 1) Support continued progress and growth of the Transgenic and Knockout Mouse Facility;2) Support continued progress and growth of the mouse Speed Congenics Facility;and 3) Support development and use of a new Human Genomics and Bioinformatics Facility. The Transgenic and Knockout Mouse Facility helps RDCC investigators produce new strains of mice by microinjection of transgenic constructs or embryonic stem cells. The Speed Congenics Facility provides custom genotyping to speed backcrossing of mice with defined alleles onto homogeneous genetic backgrounds. The new Human Genomics and Bioinformatics Facility will provide expertise in design and interpretation of high throughput genetics information. All units are devoted to testing new techniques in order to provide the RDCC community with new tools.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
2P30AR048335-11
Application #
8209393
Study Section
Special Emphasis Panel (ZAR1-MLB (M1))
Project Start
Project End
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
11
Fiscal Year
2011
Total Cost
$343,447
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Daniels, Brian P; Jujjavarapu, Harsha; Durrant, Douglas M et al. (2017) Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection. J Clin Invest 127:843-856
McCune, Broc T; Tang, Wei; Lu, Jia et al. (2017) Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine-Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2. MBio 8:
Knoop, Kathryn A; Gustafsson, Jenny K; McDonald, Keely G et al. (2017) Microbial antigen encounter during a preweaning interval is critical for tolerance to gut bacteria. Sci Immunol 2:
Elvington, Michelle; Liszewski, M Kathryn; Bertram, Paula et al. (2017) A C3(H20) recycling pathway is a component of the intracellular complement system. J Clin Invest 127:970-981
Baldridge, Megan T; Lee, Sanghyun; Brown, Judy J et al. (2017) Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus. J Virol 91:
Bern, Michael D; Beckman, Diana L; Ebihara, Takashi et al. (2017) Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor. Proc Natl Acad Sci U S A 114:E8440-E8447
Cain, Matthew D; Salimi, Hamid; Gong, Yongfeng et al. (2017) Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection. J Neuroimmunol 308:118-130
Lokki, A Inkeri; Daly, Emma; Triebwasser, Michael et al. (2017) Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population. Hypertension 70:365-371
Liszewski, M Kathryn; Elvington, Michelle; Kulkarni, Hrishikesh S et al. (2017) Complement's hidden arsenal: New insights and novel functions inside the cell. Mol Immunol 84:2-9
Smagula, Stephen F; Lotrich, Francis E; Aizenstein, Howard J et al. (2017) Immunological biomarkers associated with brain structure and executive function in late-life depression: exploratory pilot study. Int J Geriatr Psychiatry 32:692-699

Showing the most recent 10 out of 145 publications