The goal of this application for a Skin Diseases Research Center is to establish an interdisciplinary center of excellence in investigative dermatology at the University of Alabama at Birmingham (UAB). UAB is an institution with a distinguished record in promoting interactive, cooperative Centers that transcend departmental boundaries, allowing researchers to come together and focus interests on common goals. The primary emphasis of this Center will be on immunodermatology, but the effectiveness of the Center will be enhanced by inclusion of investigators in other skin-related disciplines that have unique expertise to contribute. The Center will be based in the Department of Dermatology, which has made great strides in recent years in developing programs of excellence in dermatological research. The research base of the UAB-SDRC is comprised of twenty-eight investigators from eleven different departments within the University. Each has expertise in skin disease research or has unique skills that they will contribute, through Core facility services, to enhance the quality of the skin-related research within the Center. The goals and objectives of the Center will be achieved through the establishment of three Core facilities: 1) Skin Cell Culture; 2) Tissue Resources, Molecular Analysis and Immunopathology; and 3) Skin Proteomics Core. These Cores are critical to the success of the program and will provide the members with the most current services, equipment, training and consultation in an efficient and cost-effective manner. The SDRC will also support a Pilot and Feasibility Studies program. For this application, four Pilot and Feasibility Studies were selected from nine that were submitted and accurately reflect the diversity of scientific interests within the University. An Enrichment Program will support the scientific studies and will maximize cooperative interaction at all levels. The Center will be administered by an Administrative Core, the Director and Co- Director of which, were carefully selected to coordinate an interdisciplinary approach to skin diseases research emphasizing immunodermatology. The Administrative Core will be responsible for coordinating Center activities and for enhancing communication among UAB-SDRC investigators. The ultimate goal of the SDRC will be to generate new knowledge that will have a sustained impact on cutaneous biology aimed at improving the quality of life of patients with skin diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR050948-02
Application #
6929938
Study Section
Special Emphasis Panel (ZAR1-AAA-G (J1))
Program Officer
Baker, Carl
Project Start
2004-08-01
Project End
2009-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
2
Fiscal Year
2005
Total Cost
$579,562
Indirect Cost
Name
University of Alabama Birmingham
Department
Dermatology
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Frugé, Andrew D; Van der Pol, William; Rogers, Laura Q et al. (2018) Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial. J Acad Nutr Diet :
Frugé, Andrew D; Cases, Mallory G; Howell, Carrie R et al. (2018) Fingernail and toenail clippings as a non-invasive measure of chronic cortisol levels in adult cancer survivors. Cancer Causes Control 29:185-191
Stoll, Matthew L; Pierce, M Kathy; Watkins, Jordan A et al. (2018) Akkermansia muciniphila is permissive to arthritis in the K/BxN mouse model of arthritis. Genes Immun :
Frugé, Andrew D; Ptacek, Travis; Tsuruta, Yuko et al. (2018) Dietary Changes Impact the Gut Microbe Composition in Overweight and Obese Men with Prostate Cancer Undergoing Radical Prostatectomy. J Acad Nutr Diet 118:714-723.e1
Koo, Hyunmin; Hakim, Joseph A; Powell, Mickie L et al. (2017) Metagenomics approach to the study of the gut microbiome structure and function in zebrafish Danio rerio fed with gluten formulated diet. J Microbiol Methods 135:69-76
Garcia, S S; Blackledge, M S; Michalek, S et al. (2017) Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome. J Dent Res 96:807-814
Larson, Thomas R; Yother, Janet (2017) Streptococcus pneumoniae capsular polysaccharide is linked to peptidoglycan via a direct glycosidic bond to ?-D-N-acetylglucosamine. Proc Natl Acad Sci U S A 114:5695-5700
Brawner, K M; Kumar, R; Serrano, C A et al. (2017) Helicobacter pylori infection is associated with an altered gastric microbiota in children. Mucosal Immunol 10:1169-1177
Kim, T; Holleman, C L; Ptacek, T et al. (2017) Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats. Int J Obes (Lond) 41:381-389
Sharma, Nirmal S; Wille, Keith M; Athira, S et al. (2017) Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipients. J Heart Lung Transplant :

Showing the most recent 10 out of 228 publications