The Penn Center for Musculoskeletal Disorders (PCMD) will continue to enhance the research productivity and provide critical resources and programs to investigators, with a wide variety of expertise, to address multidisciplinary research strategies for musculoskeletal problems. The overall goal of this Center is to promote a cooperative interaction among investigators to enhance the effectiveness of ongoing research and promote new research. We will continue the theme of """"""""Musculoskeletal Tissue Injury and Repair"""""""" for our Center. This theme is both broad (as it includes all musculoskeletal tissue types, such as bone, cartilage, disc, ligament, meniscus, muscle, and tendon), focused (as it includes similarities of approaches across all tissue types, with particular emphasis on applications using small animal models), and clinically significant (as it fosters development of assays, procedures and new knowledge with direct translational relevance). It is important to note that our PCMD is not a """"""""bone center"""""""", nor is it a """"""""muscle center"""""""". Indeed, one of the major strengths that differentiate our efforts is our inclusive home for all musculoskeletal researchers at Penn. Thus, the primary aims of this Center are to enhance and advance the research productivity of investigators in musculoskeletal tissue injury and repair by:
Aim 1 : Developing critical research core facilities in fundamental areas that cross disciplines and hierarchies. These core facilities are Molecular Profiling, Histology, Biomechanics, and Imaging.
Aim 2 : Developing a pilot and feasibility grant program for new and established investigators whereby new approaches, ideas, and collaborations can be developed prior to seeking extramural funding, and, Aim 3: Developing educational, training, and research enrichment programs for the musculoskeletal community spanning multiple tissue types, research approaches, and paradigms, through which investigators can learn from each other, and from national leaders, in areas where they are not expert.

Public Health Relevance

The Penn Center for Musculoskeletal Disorders will provide opportunities to integrate multi-disciplinary techniques to determine mechanisms for tissue function, injury, and repair, with an ultimate goal to advance the ability to diagnose, treat, and prevent diseases and injuries of the musculoskeletal system and its component tissues.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
2P30AR050950-06
Application #
8158771
Study Section
Special Emphasis Panel (ZAR1-KM (M1))
Program Officer
Tyree, Bernadette
Project Start
2004-04-01
Project End
2016-06-30
Budget Start
2011-07-19
Budget End
2012-06-30
Support Year
6
Fiscal Year
2011
Total Cost
$640,000
Indirect Cost
Name
University of Pennsylvania
Department
Orthopedics
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
VanBelzen, D Jake; Malik, Alock S; Henthorn, Paula S et al. (2017) Mechanism of Deletion Removing All Dystrophin Exons in a Canine Model for DMD Implicates Concerted Evolution of X Chromosome Pseudogenes. Mol Ther Methods Clin Dev 4:62-71
Robinson, Kelsey A; Sun, Mei; Barnum, Carrie E et al. (2017) Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons. Matrix Biol 64:81-93
Li, Qing; Qu, Feini; Han, Biao et al. (2017) Micromechanical anisotropy and heterogeneity of the meniscus extracellular matrix. Acta Biomater 54:356-366
Szczesny, Spencer E; Driscoll, Tristan P; Tseng, Hsiao-Yun et al. (2017) Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells. ACS Biomater Sci Eng 3:2869-2876
Chandra, Abhishek; Lin, Tiao; Young, Tiffany et al. (2017) Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. J Bone Miner Res 32:360-372
Freedman, Benjamin R; Salka, Nabeel S; Morris, Tyler R et al. (2017) Temporal Healing of Achilles Tendons After Injury in Rodents Depends on Surgical Treatment and Activity. J Am Acad Orthop Surg 25:635-647
Johnston, Jessica M; Connizzo, Brianne K; Shetye, Snehal S et al. (2017) Collagen V haploinsufficiency in a murine model of classic Ehlers-Danlos syndrome is associated with deficient structural and mechanical healing in tendons. J Orthop Res 35:2707-2715
de Bakker, Chantal Mj; Altman-Singles, Allison R; Li, Yihan et al. (2017) Adaptations in the Microarchitecture and Load Distribution of Maternal Cortical and Trabecular Bone in Response to Multiple Reproductive Cycles in Rats. J Bone Miner Res 32:1014-1026
Martin, John T; Kim, Dong Hwa; Milby, Andrew H et al. (2017) In vivo performance of an acellular disc-like angle ply structure (DAPS) for total disc replacement in a small animal model. J Orthop Res 35:23-31
Uchibe, Kenta; Son, Jiyeon; Larmour, Colleen et al. (2017) Genetic and pharmacological inhibition of retinoic acid receptor ? function promotes endochondral bone formation. J Orthop Res 35:1096-1105

Showing the most recent 10 out of 244 publications