; While musculoskeletal tissues have several biological roles, by far their primary function is to provide mechanical load support and motion to the body in response to the activities of daily living. These load and deformation requirements vary with tissue type and location, but include significant mechanical demands such as high stiffness and strength, anisotropy (direction dependence), nonlinearity (increased stiffness as deformation increases), and viscoelasticity (time dependence and energy dissipation). With injury, aging, degeneration, or disease, musculoskeletal tissues may experience a decline in mechanical function. With development, growth, and therapeutic treatment, the mechanical function can improve. In short, assessment of musculoskeletal tissue mechanics should often be primary criteria in both basic and translational studies of degradation and treatment. Moreover, the innovation and sophistication of biomechanical quantification must continue at a pace on par with the ever-deepening knowledge of musculoskeletal tissue molecular biology, with advances in molecular and imaging technologies, and with new therapeutic developments in order to discern the functional outcomes in these studies. The overall objective of this Biomechanics Core (BC) is to develop and utilize a wide range of biomechanical approaches to evaluate musculoskeletal tissue damage and repair, and to provide training and funding for new projects and collaborations utilizing these assays.
The Specific Aims are:
Aim 1 : To provide guidance and training on the capabilities, advantages, and disadvantages of the various methodologies to assess musculoskeletal tissue biomechanical function through formal educational enrichment programs and one-on-one interactions.
Aim 2 : To provide expertise and service for biomechanical assays of musculoskeletal tissues.
Aim 3 : To develop new biomechanical testing techniques that will be applicable to musculoskeletal research.
Aim 4 : To provide funding for development of new projects and collaborations and to develop preliminary and/or feasibility data for investigators.
Successful completion of these aims will significantly enhance the environment and the capabilities of researchers at the University of Pennsylvania (Penn), leading to new approaches to address musculoskeletal disorders and new collaborations between Center faculty who may have not previously included biomechanical function approaches in their musculoskeletal research programs.
|Heo, Su-Jin; Driscoll, Tristan P; Thorpe, Stephen D et al. (2016) Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. Elife 5:|
|Huegel, Julianne; Kim, Dong Hwa; Cirone, James M et al. (2016) Autologous tendon-derived cell-seeded nanofibrous scaffolds improve rotator cuff repair in an age-dependent fashion. J Orthop Res :|
|Connizzo, Brianne K; Adams, Sheila M; Adams, Thomas H et al. (2016) Multiscale regression modeling in mouse supraspinatus tendons reveals that dynamic processes act as mediators in structure-function relationships. J Biomech 49:1649-57|
|Connizzo, Brianne K; Adams, Sheila M; Adams, Thomas H et al. (2016) Collagen V expression is crucial in regional development of the supraspinatus tendon. J Orthop Res 34:2154-2161|
|McLeod, Claire M; Mauck, Robert L (2016) High fidelity visualization of cell-to-cell variation and temporal dynamics in nascent extracellular matrix formation. Sci Rep 6:38852|
|Pardes, A M; Freedman, B R; Fryhofer, G W et al. (2016) Males have Inferior Achilles Tendon Material Properties Compared to Females in a Rodent Model. Ann Biomed Eng 44:2901-10|
|Heo, Su-Jin; Han, Woojin M; Szczesny, Spencer E et al. (2016) Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophys J 111:864-74|
|Tucker, Jennica J; Riggin, Corinne N; Connizzo, Brianne K et al. (2016) Effect of overuse-induced tendinopathy on tendon healing in a rat supraspinatus repair model. J Orthop Res 34:161-6|
|Saxena, Vishal; Kim, Minwook; Keah, Niobra M et al. (2016) Anatomic Mesenchymal Stem Cell-Based Engineered Cartilage Constructs for Biologic Total Joint Replacement. Tissue Eng Part A 22:386-95|
|Han, Woojin M; Heo, Su-Jin; Driscoll, Tristan P et al. (2016) Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage. Nat Mater 15:477-84|
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