The Structure and composition of musculoskeletal tissues are tailored to meet their demanding functions. With injury, the structure and composition of these tissues deteriorate, resulting in a decline or loss of mechanical function. Musculoskeletal tissues each have a wide array of compositional and structural variety with respect to collagen and proteoglycan types, as well as other extracellular matrix constituents and factors. Careful description and quantification of tissue structural organization and composition, as well as localization and identification of growth factors and cytokines, are necessary requirements for elucidation of the biologic mechanisms underlying musculoskeletal integrity, injury, and repair. The overall objective of this Histology Core (HC) is to develop and utilize a wide range of histological and histomorphometric approaches to evaluate musculoskeletal tissue injury and repair, and to provide training and funding for new projects and collaborations utilizing these assays.
The Specific Aims are:
Aim 1 : To provide guidance and training on the capabilities, advantages, and disadvantages of the various methodologies to assess musculoskeletal tissue structure and composition through formal educational enrichment programs and one-on-one interactions.
Aim 2 : To provide expertise and service for histological and histomorphometric assays of musculoskeletal tissues.
Aim 3 : To develop new histologically-based techniques that will be applicable to musculoskeletal research.
Aim 4 : To provide funding for development of new projects and collaborations and to develop preliminary and/or feasibility data for investigators.
Successful completion of these aims will enhance the environment and the capabilities of researchers in the Penn Center for Musculoskeletal Disorders, leading to new approaches to address musculoskeletal disorders and new collaborations between Center faculty who may have not previously included structural and compositional approaches through histological examination in their musculoskeletal research programs.
|Reuther, Katherine E; Thomas, Stephen J; Tucker, Jennica J et al. (2015) Overuse activity in the presence of scapular dyskinesis leads to shoulder tendon damage in a rat model. Ann Biomed Eng 43:917-28|
|Chandra, Abhishek; Lin, Tiao; Tribble, Mary Beth et al. (2014) PTH1-34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival. Bone 67:33-40|
|Dunkman, Andrew A; Buckley, Mark R; Mienaltowski, Michael J et al. (2014) The injury response of aged tendons in the absence of biglycan and decorin. Matrix Biol 35:232-8|
|Altman, Allison R; Tseng, Wei-Ju; de Bakker, Chantal M J et al. (2014) A closer look at the immediate trabecula response to combined parathyroid hormone and alendronate treatment. Bone 61:149-57|
|Smith, Lachlan J; Gorth, Deborah J; Showalter, Brent L et al. (2014) In vitro characterization of a stem-cell-seeded triple-interpenetrating-network hydrogel for functional regeneration of the nucleus pulposus. Tissue Eng Part A 20:1841-9|
|Dishowitz, Michael I; Zhu, Fengchang; Sundararaghavan, Harini G et al. (2014) Jagged1 immobilization to an osteoconductive polymer activates the Notch signaling pathway and induces osteogenesis. J Biomed Mater Res A 102:1558-67|
|Culbert, Andria L; Chakkalakal, Salin A; Theosmy, Edwin G et al. (2014) Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification. Stem Cells 32:1289-300|
|Freedman, Benjamin R; Sarver, Joseph J; Buckley, Mark R et al. (2014) Biomechanical and structural response of healing Achilles tendon to fatigue loading following acute injury. J Biomech 47:2028-34|
|Dunkman, Andrew A; Buckley, Mark R; Mienaltowski, Michael J et al. (2014) The tendon injury response is influenced by decorin and biglycan. Ann Biomed Eng 42:619-30|
|Caro, Adam C; Tucker, Jennica J; Yannascoli, Sarah M et al. (2014) Efficacy of various analgesics on shoulder function and rotator cuff tendon-to-bone healing in a rat (Rattus norvegicus) model. J Am Assoc Lab Anim Sci 53:185-92|
Showing the most recent 10 out of 119 publications