The Penn Center for Musculoskeletal Disorders (PCMD) will continue to enhance the research productivity and provide critical resources and programs to investigators, with a wide variety of expertise, to address multidisciplinary research strategies for musculoskeletal problems. The overall goal of this Center is to promote a cooperative interaction among investigators to enhance the effectiveness of ongoing research and promote new research. We will continue the theme of """"""""Musculoskeletal Tissue Injury and Repair"""""""" for our Center. This theme is both broad (as it includes all musculoskeletal tissue types, such as bone, cartilage, disc, ligament, meniscus, muscle, and tendon), focused (as it includes similarities of approaches across all tissue types, with particular emphasis on applications using small animal models), and clinically significant (as it fosters development of assays, procedures and new knowledge with direct translational relevance). It is important to note that our PCMD is not a """"""""bone center"""""""", nor is it a """"""""muscle center"""""""". Indeed, one of the major strengths that differentiate our efforts is our inclusive home for all musculoskeletal researchers at Penn. Thus, the primary aims of this Center are to enhance and advance the research productivity of investigators in musculoskeletal tissue injury and repair by:
Aim 1 : Developing critical research core facilities in fundamental areas that cross disciplines and hierarchies. These core facilities are Molecular Profiling, Histology, Biomechanics, and Imaging.
Aim 2 : Developing a pilot and feasibility grant program for new and established investigators whereby new approaches, ideas, and collaborations can be developed prior to seeking extramural funding, and, Aim 3: Developing educational, training, and research enrichment programs for the musculoskeletal community spanning multiple tissue types, research approaches, and paradigms, through which investigators can learn from each other, and from national leaders, in areas where they are not expert.

Public Health Relevance

The Penn Center for Musculoskeletal Disorders will provide opportunities to integrate multi-disciplinary techniques to determine mechanisms for tissue function, injury, and repair, with an ultimate goal to advance the ability to diagnose, treat, and prevent diseases and injuries of the musculoskeletal system and its component tissues.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1)
Program Officer
Tyree, Bernadette
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Schools of Medicine
United States
Zip Code
Heo, Su-Jin; Driscoll, Tristan P; Thorpe, Stephen D et al. (2016) Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. Elife 5:
Huegel, Julianne; Kim, Dong Hwa; Cirone, James M et al. (2016) Autologous tendon-derived cell-seeded nanofibrous scaffolds improve rotator cuff repair in an age-dependent fashion. J Orthop Res :
Connizzo, Brianne K; Adams, Sheila M; Adams, Thomas H et al. (2016) Multiscale regression modeling in mouse supraspinatus tendons reveals that dynamic processes act as mediators in structure-function relationships. J Biomech 49:1649-57
Connizzo, Brianne K; Adams, Sheila M; Adams, Thomas H et al. (2016) Collagen V expression is crucial in regional development of the supraspinatus tendon. J Orthop Res 34:2154-2161
McLeod, Claire M; Mauck, Robert L (2016) High fidelity visualization of cell-to-cell variation and temporal dynamics in nascent extracellular matrix formation. Sci Rep 6:38852
Pardes, A M; Freedman, B R; Fryhofer, G W et al. (2016) Males have Inferior Achilles Tendon Material Properties Compared to Females in a Rodent Model. Ann Biomed Eng 44:2901-10
Heo, Su-Jin; Han, Woojin M; Szczesny, Spencer E et al. (2016) Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophys J 111:864-74
Tucker, Jennica J; Riggin, Corinne N; Connizzo, Brianne K et al. (2016) Effect of overuse-induced tendinopathy on tendon healing in a rat supraspinatus repair model. J Orthop Res 34:161-6
Saxena, Vishal; Kim, Minwook; Keah, Niobra M et al. (2016) Anatomic Mesenchymal Stem Cell-Based Engineered Cartilage Constructs for Biologic Total Joint Replacement. Tissue Eng Part A 22:386-95
Han, Woojin M; Heo, Su-Jin; Driscoll, Tristan P et al. (2016) Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage. Nat Mater 15:477-84

Showing the most recent 10 out of 217 publications