Imaging is a critically important technology for clinical, translational, cadaveric, and in vivo studies of animal and human disease. Whether the ability to characterize tissue structure or visualize molecular markers in a non-invasive manner, advanced imaging methods have proven to be powerful tools specifically for musculoskeletal applications. Research employing imaging that addresses problems in musculoskeletal injury and repair in humans has a long track record. Further, imaging is recognized to be vital as new evaluation and treatment modalities are developed and used for some of the major degenerative disorders such as osteoporosis and osteoarthritis or traumatic injuries such as fractures. The University of Pennsylvania has one of the most comprehensive imaging facilities in the nation, comprised of a complete range of imaging modalities dedicated to basic and translational research in animals and humans. Moreover, it is staffed by some of the leading scientists in the various imaging modalities. A key objective of the Penn Center for Musculoskeletal Disorders therefore is to provide an on-campus Imaging Core (IC) to musculoskeletal researchers for imaging of both humans and large and small animals. The overall objective of the IC is to develop and utilize a wide range of imaging techniques directed toward problems of musculoskeletal tissue injury and repair.
The Specific Aims are:
Aim 1 : To provide guidance and expertise on the use of imaging for musculoskeletal research through educational enrichment programs and one-on one interactions.
Aim 2 : To provide a range of imaging resources for the study of structure, function and physiology of the musculoskeletal system in laboratory animals and humans.
Aim 3 : To provide pilot funding for development of new projects and collaborations and for investigators to generate preliminary data.

Public Health Relevance

Successful completion of these Aims will significantly enhance the environment and capabilities of researchers at the University of Pennsylvania, leading to novel and innovative approaches to address musculoskeletal disorders and to new collaborations between Core faculty who may not have previously included human and/or animal imaging in their musculoskeletal research programs..

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR050950-09
Application #
8681151
Study Section
Special Emphasis Panel (ZAR1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
9
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Tian, Zuozhen; Ma, Xiaoyuan; Yasen, Miersalijiang et al. (2018) Intervertebral Disc Degeneration in a Percutaneous Mouse Tail Injury Model. Am J Phys Med Rehabil 97:170-177
Chandra, Abhishek; Wang, Luqiang; Young, Tiffany et al. (2018) Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis. FASEB J 32:52-62
Li, Qing; Wang, Chao; Han, Biao et al. (2018) Impacts of maturation on the micromechanics of the meniscus extracellular matrix. J Biomech 72:252-257
Qu, Feini; Li, Qing; Wang, Xiao et al. (2018) Maturation State and Matrix Microstructure Regulate Interstitial Cell Migration in Dense Connective Tissues. Sci Rep 8:3295
Lindborg, Carter M; Brennan, Tracy A; Wang, Haitao et al. (2018) Cartilage-derived retinoic acid-sensitive protein (CD-RAP): A stage-specific biomarker of heterotopic endochondral ossification (HEO) in fibrodysplasia ossificans progressiva (FOP). Bone 109:153-157
Amalfitano, Matthew; Fyfe, Billie; Thomas, Sumi V et al. (2018) A case report of mesenteric heterotopic ossification: Histopathologic and genetic findings. Bone 109:56-60
Freedman, Benjamin R; Rodriguez, Ashley B; Leiphart, Ryan J et al. (2018) Dynamic Loading and Tendon Healing Affect Multiscale Tendon Properties and ECM Stress Transmission. Sci Rep 8:10854
Rooney, Sarah Ilkhanipour; Torino, Daniel J; Baskin, Rachel et al. (2018) Doxycycline improves cage activity, but not exercised, supraspinatus tendon and muscle in a rat model. J Biomech 80:79-87
Brennan, Tracy A; Lindborg, Carter M; Bergbauer, Christian R et al. (2018) Mast cell inhibition as a therapeutic approach in fibrodysplasia ossificans progressiva (FOP). Bone 109:259-266
VanBelzen, D Jake; Malik, Alock S; Henthorn, Paula S et al. (2017) Mechanism of Deletion Removing All Dystrophin Exons in a Canine Model for DMD Implicates Concerted Evolution of X Chromosome Pseudogenes. Mol Ther Methods Clin Dev 4:62-71

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