The goals of the Oklahoma Rheumatic Disease Research Cores Center (ORDRCC) are to facilitate collaborative rheumatic disease research, provide cutting-edge technologies to address new clinically-relevant questions, recruit investigators with other interests/training to rheumatic disease investigation and foster development of junior investigators to independent rheumatic disease research careers. These goals are being met and have resulted in the doubling of rheumatic disease published manuscripts by our investigators, securing of new collaborative rheumatic disease research grants (for example the Autoimmunity Center of Excellence and Center of Research Translation in Sjogren's syndrome), tripling collaborative publications between ORDRCC investigators and helping launch the independent research careers of 8 local junior ORDRCC investigators and distant junior ORDRCC investigators. Our ORDRCC provides samples and experimental methodologies to a large cadre of investigators. Our ORDRCC has grown to encompass human geneticists, immunologists, immunogeneticists, bioinformaticians, epidemiologists, biostatisticians, molecular biologists, coagulation biologists and inflammation experts with pediatric and adult clinical investigators (spanning the clinical disciplines of rheumatology, dermatology, hematology/oncology, endocrinology, allergy/immunology, genetics and cardiology). This ORDRCC will continue to enhance and grow a multi-disciplinary approach to rheumatic disease research. The Administrative and Enrichment Core is the ORDRCC centralized governing resource and serves as a liaison between the ORDRCC Core leadership. Internal and External Advisory Committees, the Research Cores, and all Center investigators. In particular, the Administrative and Enrichment Core focuses on providing ORDRCC administrative and fiscal management support, executing data sharing strategies, and managing material transfer agreements. The ORDRCC Pilot Program has an annual competition which funds two junior investigators, or investigators new to rheumatology, with one year of support and has succeeded in helping investigators secure additional funding. This Core also houses the ORDRCC Mentoring program which ensures every ORDRCC Junior Investigator has an active mentoring committee. The ORDRCC Enrichment program is housed in this Core and coordinates a weekly Research Conference, weekly Work-in-Progress series, outside speakers, an annual symposium, and a proposed

Public Health Relevance

The ORDRCC Administrative and Enrichment Core provides the infrastructure necessary to coordinate and fiscally manage this multi-investigator grant; to prioritize projects to secure Core support; to forge multidisciplinary collaborations to address crucial; clinically relevant rheumatic disease questions; to foster junior investigator development through pilot project funding and mentoring support and to bring the diverse investigators and trainees together through Enrichment activities to make critical scientific discoveries.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZAR1-KM)
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Oklahoma Medical Research Foundation
Oklahoma City
United States
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Merrill, Joan T; Immermann, Fred; Whitley, Maryann et al. (2017) The Biomarkers of Lupus Disease Study: A Bold Approach May Mitigate Interference of Background Immunosuppressants in Clinical Trials. Arthritis Rheumatol 69:1257-1266
Young, Kendra A; Munroe, Melissa E; Guthridge, Joel M et al. (2017) Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus. Ann Rheum Dis 76:153-158
Zhao, Jian; Ma, Jianyang; Deng, Yun et al. (2017) A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases. Nat Genet 49:433-437
Hinks, A; Bowes, J; Cobb, J et al. (2017) Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases. Ann Rheum Dis 76:765-772
Shiboski, Caroline H; Shiboski, Stephen C; Seror, Raphaèle et al. (2017) 2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts. Arthritis Rheumatol 69:35-45
Munroe, Melissa E; Pezant, Nathan; Brown, Michael A et al. (2017) Association of IFIH1 and pro-inflammatory mediators: Potential new clues in SLE-associated pathogenesis. PLoS One 12:e0171193
Li, He; Reksten, Tove Ragna; Ice, John A et al. (2017) Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons. PLoS Genet 13:e1006820
Aberle, Teresa; Bourn, Rebecka L; Munroe, Melissa E et al. (2017) Clinical and Serologic Features in Patients With Incomplete Lupus Classification Versus Systemic Lupus Erythematosus Patients and Controls. Arthritis Care Res (Hoboken) 69:1780-1788
Talsania, Mitali; Scofield, Robert Hal (2017) Menopause and Rheumatic Disease. Rheum Dis Clin North Am 43:287-302
Munroe, Melissa E; Vista, Evan S; Merrill, Joan T et al. (2017) Pathways of impending disease flare in African-American systemic lupus erythematosus patients. J Autoimmun 78:70-78

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