The Administrative Core will manage, coordinate and evaluate all aspects of the University of Colorado Skin Diseases Research Core Center (UCAMC-SDRC), We will add Xiao-Jing Wang to our leadership team of David Norris, Dennis Roop and Richard Spritz, but will retain most features of the successful Administrative Structure from the first 4 years of funding.
This proposal will address research areas highly relevant to NIAMS priorities: biology of skin stem cells; regenerative medicine; developmental biology of the skin and appendages; melanocyte biology; keratinocyte differentiation; immune and inflammatory skin diseases; adaptive and innate immunity; identification of the genetic basis of skin disease and development of animal models to study those diseases.
|Mukherjee, Nabanita; Reuland, Steven N; Lu, Yan et al. (2015) Combining a BCL2 inhibitor with the retinoid derivative fenretinide targets melanoma cells including melanoma initiating cells. J Invest Dermatol 135:842-50|
|O'Shea, Charlene; Fitzpatrick, James E; Koch, Peter J (2014) Desmosomal defects in acantholytic squamous cell carcinomas. J Cutan Pathol 41:873-9|
|Luo, Yuchun; Cai, Xiangna; Liu, Sucai et al. (2014) Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells. Proc Natl Acad Sci U S A 111:15178-83|
|Barón, Anna E; Asdigian, Nancy L; Gonzalez, Victoria et al. (2014) Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes. Cancer Epidemiol Biomarkers Prev 23:2829-39|
|Koch, Peter J; Dinella, Jason; Fete, Mary et al. (2014) Modeling AEC-New approaches to study rare genetic disorders. Am J Med Genet A 164A:2443-54|
|Kogut, Igor; Roop, Dennis R; Bilousova, Ganna (2014) Differentiation of human induced pluripotent stem cells into a keratinocyte lineage. Methods Mol Biol 1195:1-12|
|Bilousova, Ganna; Roop, Dennis R (2014) Induced pluripotent stem cells in dermatology: potentials, advances, and limitations. Cold Spring Harb Perspect Med 4:a015164|
|Riemondy, Kent; Hoefert, Jaimee E; Yi, Rui (2014) Not miR-ly micromanagers: the functions and regulatory networks of microRNAs in mammalian skin. Wiley Interdiscip Rev RNA 5:849-65|
|Deng, Hui; Li, Fulun; Li, Hong et al. (2014) CtBP1 overexpression in keratinocytes perturbs skin homeostasis. J Invest Dermatol 134:1323-31|
|Dinella, Jason; Koster, Maranke I; Koch, Peter J (2014) Use of induced pluripotent stem cells in dermatological research. J Invest Dermatol 134:e23|
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