The University of Minnesota Muscular Dystrophy Center (UMN-MDCenter) has grown in scope and breadth since being organized to improve collaboration in basic, clinical and translational investigation of muscle biology and disease. Success of the MDCenter has recently helped recruit several prominent muscle investigators to Minnesota, capitalizing on existing strength to create what is now a unique multifaceted program focused on understanding muscle and treating muscle disease. To maximize interaction, collaboration and productivity of the expanding MDCenter, we are applying for NIAMS Core Center support with the following specific aims: 1) Core B: To strengthen and increase accessibility of a research core that provides clinical specimens to muscle investigators, and uses the CLIA-certified muscle biopsy laboratory to characterize human and animal muscle with comprehensive histological and immunostaining methods. 2) Core C: To strengthen and expand a repository of murine muscular dystrophy models for muscle investigators, which is coupled with the unique ability of our Center to characterize human and animal muscle force generation at molecular, cellular and whole tissue levels. 3) Core A: To provide administrative support for the research cores, and to establish a pilot and feasibility program for new independent investigators, which will strengthen and extend current MDCenter programs for undergraduate, graduate and post-doctoral trainees. 4) To increase institutional, regional and national awareness of UMN-MDCenter and CCMBM to enhance provision of institutional resources commensurate with the potential of this program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR057220-05
Application #
8508071
Study Section
Special Emphasis Panel (ZAR1-CHW-G (M1))
Program Officer
Nuckolls, Glen H
Project Start
2009-08-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2013
Total Cost
$573,800
Indirect Cost
$193,800
Name
University of Minnesota Twin Cities
Department
Neurology
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
McCaffrey, Jesse E; James, Zachary M; Thomas, David D (2015) Optimization of bicelle lipid composition and temperature for EPR spectroscopy of aligned membranes. J Magn Reson 250:71-5
Belanto, Joseph J; Mader, Tara L; Eckhoff, Michael D et al. (2014) Microtubule binding distinguishes dystrophin from utrophin. Proc Natl Acad Sci U S A 111:5723-8
Dong, Xiaoqiong; Thomas, David D (2014) Time-resolved FRET reveals the structural mechanism of SERCA-PLB regulation. Biochem Biophys Res Commun 449:196-201
Gruber, Simon J; Cornea, Razvan L; Li, Ji et al. (2014) Discovery of enzyme modulators via high-throughput time-resolved FRET in living cells. J Biomol Screen 19:215-22
Moen, Rebecca J; Klein, Jennifer C; Thomas, David D (2014) Electron paramagnetic resonance resolves effects of oxidative stress on muscle proteins. Exerc Sport Sci Rev 42:30-6
Mourkioti, Foteini; Kustan, Jackie; Kraft, Peggy et al. (2013) Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy. Nat Cell Biol 15:895-904
Goc, Anna; Al-Azayzih, Ahmad; Abdalla, Maha et al. (2013) P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor ýý expression and enhanced matrix metalloproteinase 9 secretion. J Biol Chem 288:3025-35
Muretta, Joseph M; Petersen, Karl J; Thomas, David D (2013) Direct real-time detection of the actin-activated power stroke within the myosin catalytic domain. Proc Natl Acad Sci U S A 110:7211-6
Moen, Rebecca J; Thomas, David D; Klein, Jennifer C (2013) Conformationally trapping the actin-binding cleft of myosin with a bifunctional spin label. J Biol Chem 288:3016-24
Arpke, Robert W; Darabi, Radbod; Mader, Tara L et al. (2013) A new immuno-, dystrophin-deficient model, the NSG-mdx(4Cv) mouse, provides evidence for functional improvement following allogeneic satellite cell transplantation. Stem Cells 31:1611-20

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