Over the past four years with the opportunity provided by the P30 CCMBM grant, our loosely organized set of musculoskeletal labs has developed into a well-respected Musculoskeletal Research Center with 75 members from 22 Departments, over 250 publications (158 in Reporter), a new facility with 12 musculoskeletal labs co-localized with the Administration and Research Cores, an active and productive Pilot and Feasibility Program, a popular Musculoskeletal Seminar Series and well-attended Annual Symposia. Our fields of interest have covered a wide variety of common musculoskeletal disorders from osteoporosis to osteoarthritis to tendon injuries to cancer. We now have $59 million in funding with $35 million from the NIH, and were recently awarded a T32 Training grant in Skeletal Metabolic Diseases. During the next five years, we plan to grow our Center to include a wider range of research interests stemming from our larger and more diverse research base, such as cancer metastasis to bone, scoliosis and intervertebral disc disease, tendon to bone healing, cartilage repair and stem cells in regenerative medicine. Our enrichment program will be expanded to include mentoring activities and training and education in specialized research techniques. The CCMBM enables the offering of many new services that will help drive the science of the research base, such as an expansion of the animal models to include zebrafish, isolation of specific populations of cells using histology and new non-invasive techniques to monitor tissue quality. Our Research Cores are: Core B: Musculoskeletal Structure and Strength, Core C: Histology and Morphometry, and Core D: Animal Models. With the help of the ICTS, we are very excited to include a new emphasis on translation of our animal research to the patient. The CCMBM will continue to provide leadership in promoting quality research, foster collaborations and interdisciplinary approaches, expand the ranks of the research base and help drive the science of musculoskeletal investigators by providing increasingly sophisticated and powerful technologies through our research cores.

Public Health Relevance

Musculoskeletal disorders such as osteoarthritis, osteoporosis and muscular dystrophy are a main cause of pain and suffering leading to diminished quality and lost time from work. Our research uses animal models to understand the biological factors underlying musculoskeletal disorders. We use histology, imaging and mechanical testing techniques to assess the structure and strength of bone, tendon and muscle.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
2P30AR057235-06
Application #
8692027
Study Section
Special Emphasis Panel ()
Program Officer
Tyree, Bernadette
Project Start
2009-05-11
Project End
2019-03-31
Budget Start
2014-04-05
Budget End
2015-03-31
Support Year
6
Fiscal Year
2014
Total Cost
$558,252
Indirect Cost
$188,448
Name
Washington University
Department
Orthopedics
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Fontana, Francesca; Hickman-Brecks, Cynthia L; Salazar, Valerie S et al. (2017) N-cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage-Specific. J Bone Miner Res 32:1332-1342
Liu, Jennifer W; Lin, Kevin H; Weber, Christian et al. (2017) An In Vitro Organ Culture Model of the Murine Intervertebral Disc. J Vis Exp :
Liu, Xiaochen; McKenzie, Jennifer A; Maschhoff, Clayton W et al. (2017) Exogenous hedgehog antagonist delays but does not prevent fracture healing in young mice. Bone 103:241-251
Hibino, Itaru; Tang, Simon (2017) Differential Carbonyl Stress Expression in the Intervertebral Disc between Singular- and Persistent-Mechanical Injuries. Nagoya Gakuin Daigaku Ronshu Igaku Kenko Kagaku Supotsu Kagakuh 5:11-19
He, Guangxu; Shi, Yu; Lim, Joohyun et al. (2017) Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth. Bone Res 5:17016
Anderson, Britta A; McAlinden, Audrey (2017) miR-483 targets SMAD4 to suppress chondrogenic differentiation of human mesenchymal stem cells. J Orthop Res 35:2369-2377
Shi, Yu; He, Guangxu; Lee, Wen-Chih et al. (2017) Gli1 identifies osteogenic progenitors for bone formation and fracture repair. Nat Commun 8:2043
Mutneja, Anubha; Cossey, L Nicholas; Liapis, Helen et al. (2017) A rare case of renal thrombotic microangiopathy associated with Castleman's disease. BMC Nephrol 18:57
Kim, Yeawon; Park, Sun-Ji; Chen, Ying Maggie (2017) Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, and therapeutic roles. Transl Res 188:1-9
Kim, Yeawon; Park, Sun-Ji; Manson, Scott R et al. (2017) Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease. JCI Insight 2:

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