The goals ofthe Administrative Core are to provide the leadership ofthe CCMBM program, and the management ofthe Research Core Facilities and Enrichment Program. The CCMBM leadership represents the two flagship Departments ofthe CCMBM (Orthopaedic Surgery and Internal Medicine, Division of Bone and Mineral Diseases) and reflects the commitment ofthe two Departments to the mission ofthis program and to musculoskeletal research at Washington University. The CCMBM has three Research Cores that provide top-quality services to members of our Research Base and to other investigators at Washington University and other institutions with interest in musculoskeletal research. In the next five years, we plan to continue providing top-quality services to our Research Base and other investigators, while developing new cutting-edge technologies and programs, hinging upon the expertise and experience built in the past four years of activities. As a new direction, we will address an area of relative underachievement, i.e. the interaction between basic and clinical researchers, with the purpose of facilitating translation of basic and animal research to the clinic for the ultimate benefit of patients with musculoskeletal disorders.
The specific aims of the Administrative Core for the next five years are:
Aim 1 - Provide Leadership ofthe CCMBM, and Integrate Core Center Components and Activities;
Aim 2 - Administer the Center Enrichment Program including a Pilot and Feasibility Grant Program, Musculoskeletal Seminar Series and Summer Educational Series, Annual Symposium and Holiday Party and Poster Session;
Aim 3 - Communication with stake holders (E-Newsletter, Website);
Aim 4 - Coordinate Core Center Activities with other Programs including a mentoring program with the T32 Metabolic Skeletal Disorders Training Grant, Institute for Clinical & Translational Science, Centerfor Regenerative Medica and over Washinton University Core Facilities;
Aim 5 - Promote Awareness and Exchange Information on the Translation of Research.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel ()
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Saint Louis
United States
Zip Code
Oladipupo, Sunday S; Smith, Craig; Santeford, Andrea et al. (2014) Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proc Natl Acad Sci U S A 111:13379-84
McAlinden, Audrey; Traeger, Geoffrey; Hansen, Uwe et al. (2014) Molecular properties and fibril ultrastructure of types II and XI collagens in cartilage of mice expressing exclusively the *1(IIA) collagen isoform. Matrix Biol 34:105-13
McAlinden, Audrey (2014) Alternative splicing of type II procollagen: IIB or not IIB? Connect Tissue Res 55:165-76
Tomlinson, Ryan E; Schmieder, Anne H; Quirk, James D et al. (2014) Antagonizing the ?v ?3 integrin inhibits angiogenesis and impairs woven but not lamellar bone formation induced by mechanical loading. J Bone Miner Res 29:1970-80
Holguin, Nilsson; Aguilar, Rhiannon; Harland, Robin A et al. (2014) The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice. J Appl Physiol (1985) 116:1551-60
Rai, Muhammad Farooq; Patra, Debabrata; Sandell, Linda J et al. (2014) Relationship of gene expression in the injured human meniscus to body mass index: a biologic connection between obesity and osteoarthritis. Arthritis Rheumatol 66:2152-64
Tatara, Alexander M; Lipner, Justin H; Das, Rosalina et al. (2014) The role of muscle loading on bone (Re)modeling at the developing enthesis. PLoS One 9:e97375
Alspach, Elise; Flanagan, Kevin C; Luo, Xianmin et al. (2014) p38MAPK plays a crucial role in stromal-mediated tumorigenesis. Cancer Discov 4:716-29
Sato, Eugene J; Killian, Megan L; Choi, Anthony J et al. (2014) Skeletal muscle fibrosis and stiffness increase after rotator cuff tendon injury and neuromuscular compromise in a rat model. J Orthop Res 32:1111-6
Hering, Thomas M; Wirthlin, Louisa; Ravindran, Soumya et al. (2014) Changes in type II procollagen isoform expression during chondrogenesis by disruption of an alternative 5' splice site within Col2a1 exon 2. Matrix Biol 36:51-63

Showing the most recent 10 out of 84 publications