Over the past four years with the opportunity provided by the P30 CCMBM grant, our loosely organized set of musculoskeletal labs has developed into a well-respected Musculoskeletal Research Center with 75 members from 22 Departments, over 250 publications (158 in Reporter), a new facility with 12 musculoskeletal labs co-localized with the Administration and Research Cores, an active and productive Pilot and Feasibility Program, a popular Musculoskeletal Seminar Series and well-attended Annual Symposia. Our fields of interest have covered a wide variety of common musculoskeletal disorders from osteoporosis to osteoarthritis to tendon injuries to cancer. We now have $59 million in funding with $35 million from the NIH, and were recently awarded a T32 Training grant in Skeletal Metabolic Diseases. During the next five years, we plan to grow our Center to include a wider range of research interests stemming from our larger and more diverse research base, such as cancer metastasis to bone, scoliosis and intervertebral disc disease, tendon to bone healing, cartilage repair and stem cells in regenerative medicine. Our enrichment program will be expanded to include mentoring activities and training and education in specialized research techniques. The CCMBM enables the offering of many new services that will help drive the science of the research base, such as an expansion of the animal models to include zebrafish, isolation of specific populations of cells using histology and new non-invasive techniques to monitor tissue quality. Our Research Cores are: Core B: Musculoskeletal Structure and Strength, Core C: Histology and Morphometry, and Core D: Animal Models. With the help of the ICTS, we are very excited to include a new emphasis on translation of our animal research to the patient. The CCMBM will continue to provide leadership in promoting quality research, foster collaborations and interdisciplinary approaches, expand the ranks of the research base and help drive the science of musculoskeletal investigators by providing increasingly sophisticated and powerful technologies through our research cores.

Public Health Relevance

Musculoskeletal disorders such as osteoarthritis, osteoporosis and muscular dystrophy are a main cause of pain and suffering leading to diminished quality and lost time from work. Our research uses animal models to understand the biological factors underlying musculoskeletal disorders. We use histology, imaging and mechanical testing techniques to assess the structure and strength of bone, tendon and muscle.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR057235-10
Application #
9481683
Study Section
Special Emphasis Panel (ZAR1)
Program Officer
Lester, Gayle E
Project Start
2009-05-11
Project End
2019-03-31
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
10
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Washington University
Department
Orthopedics
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
McKenzie, Jennifer A; Maschhoff, Clayton; Liu, Xiaochen et al. (2018) ACTIVATION OF HEDGEHOG SIGNALING BY SYSTEMIC AGONIST IMPROVES FRACTURE HEALING IN AGED MICE. J Orthop Res :
Craft, Clarissa S; Li, Ziru; MacDougald, Ormond A et al. (2018) Molecular differences between subtypes of bone marrow adipocytes. Curr Mol Biol Rep 4:16-23
Holguin, Nilsson; Silva, Matthew J (2018) In-Vivo Nucleus Pulposus-Specific Regulation of Adult Murine Intervertebral Disc Degeneration via Wnt/Beta-Catenin Signaling. Sci Rep 8:11191
Otaify, Ghada A; Whyte, Michael P; Gottesman, Gary S et al. (2018) Gnathodiaphyseal dysplasia: Severe atypical presentation with novel heterozygous mutation of the anoctamin gene (ANO5). Bone 107:161-171
Linderman, Stephen W; Golman, Mikhail; Gardner, Thomas R et al. (2018) Enhanced tendon-to-bone repair through adhesive films. Acta Biomater 70:165-176
Murali, Bhavna; Ren, Qihao; Luo, Xianmin et al. (2018) Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss. Cancer Res 78:5618-5630
Patra, Debabrata; DeLassus, Elizabeth; Mueller, Jennifer et al. (2018) Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice. Biol Open 7:
Killian, Megan L; Locke, Ryan C; James, Michael G et al. (2018) Novel model for the induction of postnatal murine hip deformity. J Orthop Res :
Shen, Hua; Jayaram, Rohith; Yoneda, Susumu et al. (2018) The effect of adipose-derived stem cell sheets and CTGF on early flexor tendon healing in a canine model. Sci Rep 8:11078
Williams, Matthew J; Sugatani, Toshifumi; Agapova, Olga A et al. (2018) The activin receptor is stimulated in the skeleton, vasculature, heart, and kidney during chronic kidney disease. Kidney Int 93:147-158

Showing the most recent 10 out of 335 publications