This P30 application, entitled "The University of Rochester Core Center for Musculoskeletal Biology and Medicine (URCCMBM)," seeks to provide shared facilities and services to the well-established, NlH funded Investigators at the University of Rochester who are addressing scientific problems in musculoskeletal biology and medicine, in order to improve efficiency, accelerate the pace of research, and facilitate clinical translation. Additionally, through its unique Enrichment Program designed to expand the research base, the URCCMBM aims to facilitate the development and promotion of Research Assistant Professors (RAP) and unfunded physician-scientists (UPS) in the Center for Musculoskeletal Research (CMSR), who have limited options for extramural funding given the recent disappearance of Foundation grants, corporate-sponsored research and University start-up packages that are critical for their career advancement. Three Cores are proposed within the URCCMBM. The Administrative Core will oversee the entire program and run the Enrichment Program that includes: Pilot Projects (targeted to RAP &UPS), a Mentoring sub-Core, a Clinical Research sub-Core, a Visiting Professor Program, Travel Grants and an Annual Research Symposium. The Histology, Biochemistry and Molecular Imaging Core will facilitate in vitro-translational research (cellular and molecular assays, histology and morphometry), and the Biomechanics and Whole Tissue Imaging Core will facilitate in vivo translational research (mechanical testing, micro-CT, in vivo multispectral and ultrasound imaging). The URCCMBM is heavily leveraged by institutional support from the School of Medicine &Dentistry and the NIH funded CTSI. The Executive Committee will review the program semiannually to ensure that URCCBMB achieves its primary goals of: improved research efficiency, fostered collaborations leading to new NIH grants, and career advancement of our RAP and UPS.
The University of Rochester Core Center for Musculoskeletal Biology and Medicine will provide shared facilities and services to NlH-funded investigators who are addressing scientific problems in musculoskeletal biology and medicine, in order to improve efficiency, accelerate the pace of research, and facilitate clinical translation. It will also facilitate the development and promotion of Research Assistant Professors (RAP) and unfunded physician-scientists (UPS) to become national leaders.
|Wang, Cuicui; Shen, Jie; Yukata, Kiminori et al. (2015) Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation. Bone 73:77-89|
|Inzana, Jason A; Schwarz, Edward M; Kates, Stephen L et al. (2015) A novel murine model of established Staphylococcal bone infection in the presence of a fracture fixation plate to study therapies utilizing antibiotic-laden spacers after revision surgery. Bone 72:128-36|
|Farhat, Youssef M; Al-Maliki, Alaa A; Easa, Anas et al. (2015) TGF-?1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair. J Cell Physiol 230:318-26|
|Long, Teng; Zhu, Zhenan; Awad, Hani A et al. (2014) The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice. Biomaterials 35:2752-9|
|Inzana, Jason A; Olvera, Diana; Fuller, Seth M et al. (2014) 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials 35:4026-34|
|David, Michael A; Jones, Khyrie H; Inzana, Jason A et al. (2014) Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes. PLoS One 9:e91234|
|Dhillon, Robinder S; Zhang, Longze; Schwarz, Edward M et al. (2014) The murine femoral bone graft model and a semiautomated histomorphometric analysis tool. Methods Mol Biol 1130:45-59|
|Varrone, John J; de Mesy Bentley, Karen L; Bello-Irizarry, Sheila N et al. (2014) Passive immunization with anti-glucosaminidase monoclonal antibodies protects mice from implant-associated osteomyelitis by mediating opsonophagocytosis of Staphylococcus aureus megaclusters. J Orthop Res 32:1389-96|
|Mack, Sarah A; Maltby, Kathleen M; Hilton, Matthew J (2014) Demineralized murine skeletal histology. Methods Mol Biol 1130:165-83|
|Jonason, Jennifer H; O'Keefe, Regis J (2014) Isolation and culture of neonatal mouse calvarial osteoblasts. Methods Mol Biol 1130:295-305|
Showing the most recent 10 out of 38 publications