The Administrative Core of the Center for Skeletal Research will have responsibility for managing the Core Facilities, the Pilot Project Program, and the Enrichment Program ofthe Center. Ms. Lynn Moulton, as Administrator, and Ms. Latanya Turner, as fiscal Officer, will assist Dr. Henry Kronenberg ((Program Director) and Dr. Marie Demay (Associate Program Director). An advisory Committee, which will include 3 members from outside institutions, will meet with this group regularly to provide advice about all aspects of management. This committee will meet four times a year with the Core Directors Committee that will meet monthly. A major principle of management will be that the Core Facilities must serve as engines of technological innovation; the anticipated changing menu of core offerings will require ongoing evaluation by the Core Directors and Advisory Committees. Another major principle is that the Core budgets will depend on user fees to cover most supply costs associated with Core services. This principle will allow the funding of several technicians who will provide services not othenwise easily obtained by Center investigators. Dr. Marie Demay will head a committee charged with the management of the Pilot and Feasibility Program. Ms. Moulton and Ms. Maclaughlin will manage the content of a Center website that will be used to coordinate and advertise Center activities and will also be interactive to allow fiscal management of all Research Cores and to allow the Cores to identify and track samples and Center investigators to communicate with each other. A seminar series will be planned to expand upon a currently existing series in a way that will expand the scope of the series and provide another setting for teaching by Core staff and feedback to the Cores from the research base. Ongoing evaluation of all programs through the polling of the research base and continually finding ways to foster collaborations will be major goals of Center leadership.
Core facilities that develop novel technologies to drive the science of a talented group of investigators will enrich the scientific potential of the investigators and further collabortion. A program to provide funds for pilot projects will focus on bringing young investigators into the field. All of these efforts will lead to novel strategies to diagnose and treat bone diseases.
|Miranda, Daniel L; Putman, Melissa; Kandah, Ruby et al. (2016) A pediatric animal model to evaluate the effects of disuse on musculoskeletal growth and development. J Biomech 49:3549-3554|
|Liu, Eva S; Martins, Janaina S; Raimann, Adalbert et al. (2016) 1,25-Dihydroxyvitamin D Alone Improves Skeletal Growth, Microarchitecture, and Strength in a Murine Model of XLH, Despite Enhanced FGF23 Expression. J Bone Miner Res 31:929-39|
|Kim, Sang Wan; Lu, Yanhui; Williams, Elizabeth A et al. (2016) Sclerostin Antibody Administration Converts Bone Lining Cells into Active Osteoblasts. J Bone Miner Res :|
|Wein, Marc N; Liang, Yanke; Goransson, Olga et al. (2016) SIKs control osteocyte responses to parathyroid hormone. Nat Commun 7:13176|
|Fan, Yi; Bi, Ruiye; Densmore, Michael J et al. (2016) Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis. FASEB J 30:428-40|
|Eda, Homare; Santo, Loredana; Wein, Marc N et al. (2016) Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease. J Bone Miner Res 31:1225-34|
|Mirzamohammadi, Fatemeh; Papaioannou, Garyfallia; Inloes, Jennifer B et al. (2016) Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-Î² signalling. Nat Commun 7:12047|
|Hattersley, Gary; Dean, Thomas; Corbin, Braden A et al. (2016) Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling. Endocrinology 157:141-9|
|Song, Lige; Papaioannou, Garyfallia; Zhao, Hengguang et al. (2016) The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury. Endocrinology 157:4066-4075|
|Liu, Eva S; Raimann, Adalbert; Chae, Byongsoo Timothy et al. (2016) c-Raf promotes angiogenesis during normal growth plate maturation. Development 143:348-55|
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