Identification of the structural, architectural, cellular and molecular basis for the skeletal phenotypes that result from genetic/pharmacologic interventions and disease states is essential for translating scientific discoveries into therapeutic innovations. The goal of the Skeletal Phenotyping Core is to provide costefficient, state ofthe art, quality-controlled skeletal phenotyping services to fulfill the unmet needs of junior investigators who are transitioning to an independent career in skeletal biology, of established investigators who are new to skeletal biology and of established skeletal biologists. A key part ofthe mission ofthe Skeletal Phenotyping Core will be education, mentoring and incorporation of novel and innovative services to meet the needs ofthe constituent investigators. Consultation regarding experimental design, specimen handling and data analysis will be provided by Core directors, to insure that the maximal amount of data can be obtained from each specimen/subject. The Core will host didactic teaching sessions, hands-on workshops and seminars designed to educate investigators and to foster collaboration among investigators. A special focus ofthe Core will be mentorship of junior investigators and of those investigators new to skeletal biology. This infrastructure and these activities will 1) enhance the productivity and expand the scope of research being conducted by the Core investigators, 2) promote innovation and incorporation of novel technologies into core services 3) foster synergy across a large and diverse community interested in skeletal research, ultimately leading to levels of success greater than the sum of the individual investigators' projected achievements. This will be achieved by the following specific Aims:
Aim 1 : Provide efficient, high-quality, state-of-the-art skeletal phenotyping services that are not readily supported by individual research grants;
Aim 2 : Provide shared resources, training, and educational services to support new investigators in skeletal biology and to facilitate collaboration among core investigators.
The Skeletal Phenotyping Core will provide state ofthe art|services, training in relevant methodologies and assistance with study design and interpretation of results. The Core will also enhance research by providing access to technologies or expertise that would otherwise not otherwise be available to individual investigators. Through its mentoring of Junior investigators, seminars and hands-on workshops, the Core will enhance the success of established investigators and expand the community of skeletal biologists.
|Saini, Vaibhav; Zhao, Hengguang; Petit, Elizabeth T et al. (2017) Absence of vitamin D receptor (VDR)-mediated PPAR? suppression causes alopecia in VDR-null mice. FASEB J 31:1059-1066|
|Fulzele, Keertik; Lai, Forest; Dedic, Christopher et al. (2017) Osteocyte-Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots. J Bone Miner Res 32:373-384|
|Roszko, Kelly L; Bi, Ruiye; Gorvin, Caroline M et al. (2017) Knockin mouse with mutant G?11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors. JCI Insight 2:e91079|
|Papaioannou, Garyfallia; Petit, Elizabeth T; Liu, Eva S et al. (2017) Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development. J Biol Chem 292:3164-3171|
|Kitano, Kentaro; Schwartz, Dana M; Zhou, Haiyang et al. (2017) Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts. Nat Commun 8:765|
|Bornstein, Sheila; Moschetta, Michele; Kawano, Yawara et al. (2017) Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice. Endocrinology 158:3369-3385|
|Engblom, Camilla; Pfirschke, Christina; Zilionis, Rapolas et al. (2017) Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science 358:|
|Li, Yuwen; Caballero, Daniel; Ponsetto, Julian et al. (2017) Response of Npt2a knockout mice to dietary calcium and phosphorus. PLoS One 12:e0176232|
|He, Qing; Bouley, Richard; Liu, Zun et al. (2017) Large G protein ?-subunit XL?s limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo. Proc Natl Acad Sci U S A 114:E9559-E9568|
|Guo, Jun; Khatri, Ashok; Maeda, Akira et al. (2017) Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment. J Bone Miner Res 32:86-98|
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