The overall goal of the Cincinnati Rheumatic Diseases Resource Center (CRDRC) is to promote biomedical research that yields insights into fundamental processes and pathogenic mechanisms of rheumatic diseases in children, which can lead to innovative treatments for these diseases.
The aims of the CRDRC are to 1) to provide resources that enhance the scope and breadth of the overall research community to advance the understanding of pediatric rheumatic disease and 2) to foster collaborations and interdisciplinary approaches to promote laboratory discoveries, generate translational research opportunities that ultimately impact patient care. The CRDRC will support projects with potential to advance the national research agenda related to rheumatic diseases, and that represent an area of tremendous strength and resource investment at Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine. The CRDRC will offer four innovative research-based resources, including a Pediatric Rheumatology Tissue Repository, a Single Cell Phenotyping Core, a Functional Genomics Core and a Rheumatology Informatics Core. Collectively, these resources form a powerful infrastructure that fosters development of precision and predictive medical approaches based on genomics and disease mechanisms. The CRDRC will support disease-based research across the continuum of discovery, where laboratory findings generate translational studies that lead to clinical trials. In addition to advancing knowledge of pediatric rheumatic disease, the goals of the CRDRC include recruitment of established investigators to bring new expertise to the field, cultivation of collaborations within the local and national research community, and encouragement of young investigators committed to pursuing research careers focused on pediatric rheumatic disease. These goals of the CRDRC are particularly well supported by a Pilot & Feasibility Study Program that will transcend the Cincinnati research community to include pediatric rheumatology investigators across the US. The CRDRC also will strengthen the research community through an enrichment program of local seminars, workshops and symposia. A highly accomplished and collaborative community of researchers is already in place creating fertile ground for accomplishing the goals of the Cincinnati Center, and ultimately to accelerate research to benefit pediatric rheumatic disease patients in their care.
The Cincinnati Rheumatic Diseases Resource Center will promote biomedical research that yields insights into fundamental processes and pathogenic mechanisms of rheumatic diseases in children. This will be done by coordinating resources and core services as well as promoting interdivisional, interdepartmental and national collaborations.
|Ogdie, Alexis; Sparks, Jeffrey A; Angeles-Han, Sheila T et al. (2018) Barriers and Facilitators of Mentoring for Trainees and Early Career Investigators in Rheumatology Research: Current State, Identification of Needs, and Road Map to an Inter-Institutional Adult Rheumatology Mentoring Program. Arthritis Care Res (Hoboken) 70:445-453|
|Martin, Lisa J; He, Hua; Collins, Margaret H et al. (2018) Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci. J Allergy Clin Immunol 141:1690-1698|
|Patterson, Andrew R; Endale, Mehari; Lampe, Kristin et al. (2018) Gimap5-dependent inactivation of GSK3? is required for CD4+ T cell homeostasis and prevention of immune pathology. Nat Commun 9:430|
|Hinks, Anne; Marion, Miranda C; Cobb, Joanna et al. (2018) Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis. Arthritis Rheumatol 70:957-962|
|Patel, Zubin; Lu, Xiaoming; Miller, Daniel et al. (2018) A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Hum Mol Genet :|
|Sherrill, Joseph D; Kc, Kiran; Wang, Xinjian et al. (2018) Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis. JCI Insight 3:|
|Gohar, Faekah; Anink, Janneke; Moncrieffe, Halima et al. (2018) S100A12 Is Associated with Response to Therapy in Juvenile Idiopathic Arthritis. J Rheumatol 45:547-554|
|Nigrovic, Peter A; Raychaudhuri, Soumya; Thompson, Susan D (2018) Review: Genetics and the Classification of Arthritis in Adults and Children. Arthritis Rheumatol 70:7-17|
|Brunner, Hermine I; Holland, Michael; Beresford, Michael W et al. (2018) American College of Rheumatology Provisional Criteria for Global Flares in Childhood-Onset Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken) 70:813-822|
|Ohl, Kim; Nickel, Helge; Moncrieffe, Halima et al. (2018) The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis. Pediatr Rheumatol Online J 16:39|
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