The Dana-Farber/Harvard Cancer Center (DF/HCC) Breast Cancer Program seeks to gain a better understanding of breast cancer prevention, risk assessment, epidemiology, genetics and molecular biology, with the hope of translating these findings into meaningful prevention strategies for women at risk of breast cancer and new treatment approaches for those diagnosed with the disease. With the recognition of biologically and clinically distinct breast cancer subtypes, the Breast Cancer Program has increasingly focused on subtypes of the disease. In the next five years, substantive contributions are anticipated in the molecular characterization and treatment of triple-negative disease, HER2+ disease and hormone receptor positive disease. The Program will continue to focus on the development of targeted treatment strategies within molecular subtypes and identify mechanisms of drug resistance. The Breast Cancer Program has been continuously approved by the NCI as an Established Research Program since the inception of the Center. At the time of the last competitive renewal, the Program received """"""""outstanding"""""""" merit. The 110 members span all seven DF/HCC institutions and represent 15 departments of HMS and two departments of HSPH. Members currently have $28.7 million in peer-reviewed funding (TC), of which nearly $18 million is from NCI. At the time of the prior competitive renewal, peer-reviewed funding was $16 million, of which $10.1 million was from NCI. This funding total includes several new grants including a V Foundation Award, a Stand Up 2 Cancer award that crosses multiple institutions within and outside of DF/HCC and a Susan G. Komen for the Cure Promise Grant focused on prevention. Program members have published 891 papers during the project period of which 17% were intra-programmatic, 38% were inter-programmatic and 24% were interinstitutional, which reflects a high level of productivity and collaboration. The funding and publication record reflects the broad research base of the Program collaboration among breast cancer researchers.

Public Health Relevance

The DF/HCC Breast Cancer Program is dedicated to reducing the burden from breast cancer by reducing the incidence, morbidity and mortality of the disease. This overarching goal will be achieved through strong multidisciplinary collaboration. The Program seeks to understand the complex biological underpinnings of the disease and apply this knowledge to the design of clinical trials and to clinical practice.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA006516-47
Application #
8227547
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-05-15
Budget End
2012-11-30
Support Year
47
Fiscal Year
2012
Total Cost
$93,207
Indirect Cost
$69,350
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
Lin, Ruei-Zeng; Lee, Chin Nien; Moreno-Luna, Rafael et al. (2017) Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks. Nat Biomed Eng 1:
Wang, Meng; Han, Jing; Marcar, Lynnette et al. (2017) Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway. Cancer Res 77:2018-2028
Ignatius, Myron S; Hayes, Madeline N; Lobbardi, Riadh et al. (2017) The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. Cell Rep 19:2304-2318
Nugent, Alicia A; Park, Jong G; Wei, Yan et al. (2017) Mutant ?2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome. J Clin Invest 127:1664-1682
Breitkopf, Susanne B; Taveira, Mateus De Oliveira; Yuan, Min et al. (2017) Serial-omics of P53-/-, Brca1-/- Mouse Breast Tumor and Normal Mammary Gland. Sci Rep 7:14503
Bowden, John A; Heckert, Alan; Ulmer, Candice Z et al. (2017) Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma. J Lipid Res 58:2275-2288
Lindsley, R Coleman; Saber, Wael; Mar, Brenton G et al. (2017) Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation. N Engl J Med 376:536-547
Mita, Monica M; Mita, Alain C; Moseley, Jennifer L et al. (2017) Phase 1 safety, pharmacokinetic and pharmacodynamic study of the cyclin-dependent kinase inhibitor dinaciclib administered every three weeks in patients with advanced malignancies. Br J Cancer 117:1258-1268
Hu, Yuebi; Alden, Ryan S; Odegaard, Justin I et al. (2017) Discrimination of Germline EGFR T790M Mutations in Plasma Cell-Free DNA Allows Study of Prevalence Across 31,414 Cancer Patients. Clin Cancer Res 23:7351-7359
Lam, Hilaire C; Liu, Heng-Jia; Baglini, Christian V et al. (2017) Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells. Oncotarget 8:64714-64727

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