The Dana-Farber/Harvard Cancer Center (DF/HCC) Breast Cancer Program seeks to gain a better understanding of breast cancer prevention, risk assessment, epidemiology, genetics and molecular biology, with the hope of translating these findings into meaningful prevention strategies for women at risk of breast cancer and new treatment approaches for those diagnosed with the disease. With the recognition of biologically and clinically distinct breast cancer subtypes, the Breast Cancer Program has increasingly focused on subtypes of the disease. In the next five years, substantive contributions are anticipated in the molecular characterization and treatment of triple-negative disease, HER2+ disease and hormone receptor positive disease. The Program will continue to focus on the development of targeted treatment strategies within molecular subtypes and identify mechanisms of drug resistance. The Breast Cancer Program has been continuously approved by the NCI as an Established Research Program since the inception of the Center. At the time of the last competitive renewal, the Program received "outstanding" merit. The 110 members span all seven DF/HCC institutions and represent 15 departments of HMS and two departments of HSPH. Members currently have $28.7 million in peer-reviewed funding (TC), of which nearly $18 million is from NCI. At the time of the prior competitive renewal, peer-reviewed funding was $16 million, of which $10.1 million was from NCI. This funding total includes several new grants including a V Foundation Award, a Stand Up 2 Cancer award that crosses multiple institutions within and outside of DF/HCC and a Susan G. Komen for the Cure Promise Grant focused on prevention. Program members have published 891 papers during the project period of which 17% were intra-programmatic, 38% were inter-programmatic and 24% were interinstitutional, which reflects a high level of productivity and collaboration. The funding and publication record reflects the broad research base of the Program collaboration among breast cancer researchers.

Public Health Relevance

The DF/HCC Breast Cancer Program is dedicated to reducing the burden from breast cancer by reducing the incidence, morbidity and mortality of the disease. This overarching goal will be achieved through strong multidisciplinary collaboration. The Program seeks to understand the complex biological underpinnings of the disease and apply this knowledge to the design of clinical trials and to clinical practice.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA006516-48
Application #
8469401
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
48
Fiscal Year
2013
Total Cost
$85,483
Indirect Cost
$63,431
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
Hu, Yanhui; Comjean, Aram; Roesel, Charles et al. (2016) FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2017 update. Nucleic Acids Res :
Hong, Theodore S; Wo, Jennifer Y; Yeap, Beow Y et al. (2016) Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. J Clin Oncol 34:460-8
Freedman, Rachel A; Gelman, Rebecca S; Wefel, Jeffrey S et al. (2016) Translational Breast Cancer Research Consortium (TBCRC) 022: A Phase II Trial of Neratinib for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases. J Clin Oncol 34:945-52
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McKay, Tina B; Hjortdal, Jesper; Sejersen, Henrik et al. (2016) Endocrine and Metabolic Pathways Linked to Keratoconus: Implications for the Role of Hormones in the Stromal Microenvironment. Sci Rep 6:25534
Nelms, Bradlee D; Waldron, Levi; Barrera, Luis A et al. (2016) CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol 17:201
Tan, Justin L; Fogley, Rachel D; Flynn, Ryan A et al. (2016) Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Mol Cell 62:34-46
Johnson, Shawn F; Cruz, Cristina; Greifenberg, Ann Katrin et al. (2016) CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer. Cell Rep 17:2367-2381

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