The DF/HCC Lymphoma and IVlyeloma Program includes a multidisciplinary group of 66 investigators from seven DF/HCC institutions who work together to explore the causes, define the pathogenetic mechanisms and improve the therapy of lymphoid neoplasms. At the time of the last CCSG renewal the Program received an Excellent to Outstanding merit score. Lymphoma and Myeloma Program members are: 1) experts in many of the most common lymphoid malignancies;2) investigators with lymphoma and myeloma research programs spanning basic, translational and clinical areas;3) dedicated clinical investigators;4) hematopathologists with demonstrated expertise in lymphoid malignancies;and 5) biostatisticians who specialize in these diseases. DF/HCC provides a mechanism for these lymphoma/myeloma investigators to have a cohesive program of basic and clinical investigation based upon complementary and synergistic areas of expertise. Program investigators received over $12.7 million peer-reviewed support in 2009, of which $7.5 million was from NCI funding. They also published 691 papers (33% intra-programmatic, 48% inter-programmatic and 37% inter-institutional) in the current funding period (2006 to 2010). The Lymphoma and Myeloma Program has the following specific objectives: 1) elucidate pathogenetic mechanisms underiying specific lymphoid neoplasms;2) develop novel therapeutic approaches to lymphoid malignancies;and 3) evaluate treatment outcomes and long-term complications in lymphoma and myeloma patients..
The Lymphoma and Myeloma Program is committed to characterizing specific lymphoid malignancies at both a cellular and molecular level using state-of-the-art approaches including informative in vivo models and comprehensive analysis of molecular signatures. In addition to gaining basic insights into pathogenetic mechanisms and predispo treatment targets.
|Lin, Ruei-Zeng; Lee, Chin Nien; Moreno-Luna, Rafael et al. (2017) Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks. Nat Biomed Eng 1:|
|Wang, Meng; Han, Jing; Marcar, Lynnette et al. (2017) Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway. Cancer Res 77:2018-2028|
|Ignatius, Myron S; Hayes, Madeline N; Lobbardi, Riadh et al. (2017) The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. Cell Rep 19:2304-2318|
|Nugent, Alicia A; Park, Jong G; Wei, Yan et al. (2017) Mutant ?2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome. J Clin Invest 127:1664-1682|
|Breitkopf, Susanne B; Taveira, Mateus De Oliveira; Yuan, Min et al. (2017) Serial-omics of P53-/-, Brca1-/- Mouse Breast Tumor and Normal Mammary Gland. Sci Rep 7:14503|
|Bowden, John A; Heckert, Alan; Ulmer, Candice Z et al. (2017) Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma. J Lipid Res 58:2275-2288|
|Lindsley, R Coleman; Saber, Wael; Mar, Brenton G et al. (2017) Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation. N Engl J Med 376:536-547|
|Mita, Monica M; Mita, Alain C; Moseley, Jennifer L et al. (2017) Phase 1 safety, pharmacokinetic and pharmacodynamic study of the cyclin-dependent kinase inhibitor dinaciclib administered every three weeks in patients with advanced malignancies. Br J Cancer 117:1258-1268|
|Hu, Yuebi; Alden, Ryan S; Odegaard, Justin I et al. (2017) Discrimination of Germline EGFR T790M Mutations in Plasma Cell-Free DNA Allows Study of Prevalence Across 31,414 Cancer Patients. Clin Cancer Res 23:7351-7359|
|Lam, Hilaire C; Liu, Heng-Jia; Baglini, Christian V et al. (2017) Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells. Oncotarget 8:64714-64727|
Showing the most recent 10 out of 371 publications