Cancer cytogenetics expertise is needed to provide critical data for research projects in many Programs of the Sidney Kimmel Comprehensive Cancer Center (SKCCC). The Cancer Cytogenetics Shared Resource has been providing such expertise to SKCCC researchers since 1986. A full array of analyses is offered;these include metaphase analysis using traditional G-banding and fluorescent in situ hybridization (FISH) technologies, ranging from single locus probes through multicolor FISH including Spectral Karyotyping (SKY). Consultations to determine the best cytogenetic technique to answer the investigator's question are an integral part of the service provided. Up-to-date techniques and highly experienced personnel have been the foundation of this facility and provide major value to the users. The Core also coordinates with services offered by the Tissue Microarray Core, such as tissue in-situ hybridization, and the Microarray Core, such as genomic copy-number and SNP-chip assays, to provide a seamless continuum of genomic analysis technologies in the SKCCC. Lay: The Cytogenetics Core Resource provides expert analysis of chromosomes, the structures that carry our DNA. Chromosome abnormalities in cancer are common, and researchers often need characterization of chromosome changes that are present in cancer cell lines.
| Martin, Allison M; Nirschl, Christopher J; Polanczyk, Magda J et al. (2018) PD-L1 expression in medulloblastoma: an evaluation by subgroup. Oncotarget 9:19177-19191 |
| Yeruva, Sri Lakshmi Hyndavi; Javadi, Mehrbod Som; Stearns, Vered (2018) Complete Response to Single-agent Palbociclib in Metastatic Breast Cancer: A Case Report. Clin Breast Cancer 18:e277-e280 |
| Zarif, Jelani C; Chalfin, Heather J; Pierorazio, Phillip M et al. (2018) Characterization of the Macrophage Infiltrate in a Case of Xanthogranulomatous Pyelonephritis. J Clin Urol 11:226-228 |
| Rowe, Steven P; Luber, Brandon; Makell, Monique et al. (2018) From validity to clinical utility: the influence of circulating tumor DNA on melanoma patient management in a real-world setting. Mol Oncol 12:1661-1672 |
| Chung, Liam; Thiele Orberg, Erik; Geis, Abby L et al. (2018) Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. Cell Host Microbe 23:203-214.e5 |
| LaFleur, Martin W; Muroyama, Yuki; Drake, Charles G et al. (2018) Inhibitors of the PD-1 Pathway in Tumor Therapy. J Immunol 200:375-383 |
| McDevitt, Michael R; Thorek, Daniel L J; Hashimoto, Takeshi et al. (2018) Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer. Nat Commun 9:1629 |
| Shah, Tariq; Krishnamachary, Balaji; Wildes, Flonne et al. (2018) Molecular causes of elevated phosphoethanolamine in breast and pancreatic cancer cells. NMR Biomed 31:e3936 |
| Peprah, Sally; Curreiro, Frank C; Hayes, Jennifer H et al. (2018) A spatiotemporal analysis of invasive cervical cancer incidence in the state of Maryland between 2003 and 2012. Cancer Causes Control 29:445-453 |
| Springer, Simeon U; Chen, Chung-Hsin; Rodriguez Pena, Maria Del Carmen et al. (2018) Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy. Elife 7: |
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