The Specimen Accessioning Core (SAC) provides a centralized resource for the collection and processing of blood, bone marrow, and tumor cell samples from patients with malignancies as well as samples from normal volunteer donors. This Core was initially established in order to facilitate and support the ongoing laboratory and clinical research within the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (SKCCC). In addition, the SAC provides rigorous quality assurance and quality control for the processing and storage of clinical samples. Thus, the specific aims of this Core are to: 1) Centralize accessioning of patient specimens, 2) Process patient specimens and tissue samples utilizing good laboratory practices (GLP) procedures, 3) Store specimens in a well-controlled and monitored environment in order to ensure sample integrity, 4) Fairly and equitably distribute accessioned samples to investigators with IRB-approved research questions. 5) Maintain a secure relational data base that includes detailed information on the handling and processing of the samples along with pertinent clinical and demographic data that correlate to the specimen. 6) Provide expertise and support to investigators in the planning of sample collection for the development of correlative biologic tests for clinical trials and for pharmacokinetic/pharmacodynamic analysis and, 7) Provide a mechanism to ensure that informed consent is provided and subjects are maximally protected when volunteering to donate tissues for ongoing and future research by maintaining an active IRB-approved clinical trial (currently RPN#00-01-27-09, Tissue and Cell Procurement Protocol) that identified the research nature of the bank and assures HIPAA-compliances. Lay: The Specimen Accessioning Core laboratory processes samples including blood, urine and bone marrow from patients treated with a variety of new anti cancer drugs in order to test the samples for the effectiveness of these new anti-cancer drugs and to determine how these drugs are metabolized by the patients. The Specimen Accessioning Core laboratory also processes and banks a variety of tumors from patients with hematologic (blood) cancers and makes the cancer cells available to investigators within the cancer center for study in the laboratory.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA006973-50
Application #
8559758
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
50
Fiscal Year
2013
Total Cost
$89,072
Indirect Cost
$34,088
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Hurley, Paula J; Sundi, Debasish; Shinder, Brian et al. (2016) Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer. Clin Cancer Res 22:448-58
Roberts, Nicholas J; Norris, Alexis L; Petersen, Gloria M et al. (2016) Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer. Cancer Discov 6:166-75
Chen, Zhihang; Penet, Marie-France; Krishnamachary, Balaji et al. (2016) PSMA-specific theranostic nanoplex for combination of TRAIL gene and 5-FC prodrug therapy of prostate cancer. Biomaterials 80:57-67
Castanares, Mark A; Copeland, Ben T; Chowdhury, Wasim H et al. (2016) Characterization of a novel metastatic prostate cancer cell line of LNCaP origin. Prostate 76:215-25
Anders, Nicole M; Wanjiku, Teresia M; He, Ping et al. (2016) A robust and rapid liquid chromatography tandem mass spectrometric method for the quantitative analysis of 5-azacytidine. Biomed Chromatogr 30:494-6
Morgan, Michael T; Haj-Yahya, Mahmood; Ringel, Alison E et al. (2016) Structural basis for histone H2B deubiquitination by the SAGA DUB module. Science 351:725-8
Mao, Kai; Liu, Jieqiong; Sun, Jian et al. (2016) Patterns and prognostic value of lymph node dissection for resected perihilar cholangiocarcinoma. J Gastroenterol Hepatol 31:417-26
Morais, Carlos L; Guedes, Liana B; Hicks, Jessica et al. (2016) ERG and PTEN status of isolated high-grade PIN occurring in cystoprostatectomy specimens without invasive prostatic adenocarcinoma. Hum Pathol 55:117-25
Wang, Zhijun; Hansis, Eberhard; Chen, Rongxin et al. (2016) Automatic bone removal for 3D TACE planning with C-arm CBCT: Evaluation of technical feasibility. Minim Invasive Ther Allied Technol 25:162-70
Vrooman, Lynda M; Kirov, Ivan I; Dreyer, ZoAnn E et al. (2016) Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli-Derived Asparaginase in Children and Adolescents With Acute Lymphoblastic Leukemia. Pediatr Blood Cancer 63:228-33

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