The McArdle Laboratory Safety and Biohazard Committee is composed of four faculty members, Drs. Kasper *chairman), Panganiban, Loeb, and Ross, Ronald Kaehler, representatives from the trainees and technical staff and Dr. Ilse Riegel. The responsibilities of this Committee are to promote the development of safety-minded and safety-educated personnel and to help to ensure that safe produces are followed throughout the McArdle building. The Center's committee works with the Safety Department and the Biological Safety Committee of the University of Wisconsin-Madison. The University Safety Department handles the ordering, monitoring of use, and disposal of radioactive materials; is charged with the disposal of flammable and/or hazardous chemicals; collects unneeded chemicals; and monitors the functioning of a variety of safety equipment, including fire extinguishers, safety showers, and chemical hoods. The Biological Safety Committee of the University monitors the use of biological materials (viruses, bacteria, cell cultures) and of nonradioactive toxic chemicals (mutagens, carcinogens, etc.) The UW Biological Safety Committee also certifies the 42 biological safety cabinets in the McArdle Laboratory. In addition, it has the responsibility of certifying the HEPA-filter-equipped disposal units and the HEPA-filtered cage unit in the Animal Care Facility, as well as the HEPA filters on the exhaust system from the chemical treatment rooms of the B wing animal unit.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA007175-36
Application #
6299907
Study Section
Project Start
2000-04-01
Project End
2001-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
36
Fiscal Year
2000
Total Cost
$216,384
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Thompson, Nancy E; Glaser, Bryan T; Foley, Katherine M et al. (2009) Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB. J Biol Chem 284:24754-66
Habig, Jeffrey W; Loeb, Daniel D (2006) Sequence identity of the direct repeats, DR1 and DR2, contributes to the discrimination between primer translocation and in situ priming during replication of the duck hepatitis B virus. J Mol Biol 364:32-43
Liu, Ning; Ji, Lin; Maguire, Megan L et al. (2004) cis-Acting sequences that contribute to the synthesis of relaxed-circular DNA of human hepatitis B virus. J Virol 78:642-9
Tessier, Charles R; Doyle, Glenn A; Clark, Brad A et al. (2004) Mammary tumor induction in transgenic mice expressing an RNA-binding protein. Cancer Res 64:209-14
Ostrow, Kristin M; Loeb, Daniel D (2004) Underrepresentation of the 3' region of the capsid pregenomic RNA of duck hepatitis B virus. J Virol 78:2179-86
Habig, Jeffrey W; Loeb, Daniel D (2003) Template switches during plus-strand DNA synthesis of duck hepatitis B virus are influenced by the base composition of the minus-strand terminal redundancy. J Virol 77:12412-20
Habig, Jeffrey W; Loeb, Daniel D (2003) The conformation of the 3' end of the minus-strand DNA makes multiple contributions to template switches during plus-strand DNA synthesis of duck hepatitis B virus. J Virol 77:12401-11
Bunger, Maureen K; Moran, Susan M; Glover, Edward et al. (2003) Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor. J Biol Chem 278:17767-74
Liu, Ning; Tian, Ru; Loeb, Daniel D (2003) Base pairing among three cis-acting sequences contributes to template switching during hepadnavirus reverse transcription. Proc Natl Acad Sci U S A 100:1984-9
Mueller-Hill, Karlyn; Loeb, Daniel D (2002) cis-Acting sequences 5E, M, and 3E interact to contribute to primer translocation and circularization during reverse transcription of avian hepadnavirus DNA. J Virol 76:4260-6

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